3OKH
Crystal structure of human FXR in complex with 2-(4-chlorophenyl)-1-[(1S)-1-cyclohexyl-2-(cyclohexylamino)-2-oxoethyl]-1H-benzimidazole-6-carboxylic acid
Summary for 3OKH
Entry DOI | 10.2210/pdb3okh/pdb |
Related | 3OKI 3OLF 3OMK 3OMM 3OOF 3OOK |
Descriptor | Bile acid receptor, peptide of Nuclear receptor coactivator 1, 2-(4-chlorophenyl)-1-[(1S)-1-cyclohexyl-2-(cyclohexylamino)-2-oxoethyl]-1H-benzimidazole-6-carboxylic acid, ... (4 entities in total) |
Functional Keywords | nuclear receptor, cholesterol, bile acid, dna-binding, nucleus, receptor, transcription, ligand binding domain transcription regulation, coactivator, fxr alternative splicing, hormone receptor |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus (Probable): Q96RI1 Nucleus (By similarity): Q15788 |
Total number of polymer chains | 2 |
Total formula weight | 29878.27 |
Authors | Rudolph, M.G. (deposition date: 2010-08-25, release date: 2010-12-29, Last modification date: 2024-04-03) |
Primary citation | Richter, H.G.F.,Benson, G.M.,Blum, D.,Chaput, E.,Feng, S.,Gardes, C.,Grether, U.,Hartman, P.,Kuhn, B.,Martin, R.E.,Plancher, J.-M.,Rudolph, M.G.,Schuler, F.,Taylor, S.,Bleicher, K.H. Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes Bioorg.Med.Chem.Lett., 21:191-194, 2010 Cited by PubMed: 21134747DOI: 10.1016/j.bmcl.2010.11.039 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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