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3OKI

Crystal structure of human FXR in complex with (2S)-2-[2-(4-chlorophenyl)-1H-benzimidazol-1-yl]-N,2-dicyclohexylethanamide

Summary for 3OKI
Entry DOI10.2210/pdb3oki/pdb
Related3OKH 3OLF 3OMK 3OMM 3OOF 3OOK
DescriptorBile acid receptor, peptide of Nuclear receptor coactivator 1, (2S)-2-[2-(4-chlorophenyl)-1H-benzimidazol-1-yl]-N,2-dicyclohexylethanamide, ... (4 entities in total)
Functional Keywordsnuclear receptor, cholesterol, bile acid, dna-binding, nucleus, receptor, transcription, ligand binding domain transcription regulation, coactivator, fxr alternative splicing, hormone receptor
Biological sourceHomo sapiens (human)
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Cellular locationNucleus (Probable): Q96RI1
Nucleus (By similarity): Q15788
Total number of polymer chains4
Total formula weight58680.46
Authors
Rudolph, M.G. (deposition date: 2010-08-25, release date: 2010-12-29, Last modification date: 2024-03-20)
Primary citationRichter, H.G.F.,Benson, G.M.,Blum, D.,Chaput, E.,Feng, S.,Gardes, C.,Grether, U.,Hartman, P.,Kuhn, B.,Martin, R.E.,Plancher, J.-M.,Rudolph, M.G.,Schuler, F.,Taylor, S.,Bleicher, K.H.
Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes
Bioorg.Med.Chem.Lett., 21:191-194, 2010
Cited by
PubMed: 21134747
DOI: 10.1016/j.bmcl.2010.11.039
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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