3MNP

Crystal structure of the agonist form of mouse glucocorticoid receptor stabilized by (A611V, V708A, E711G) mutations at 1.50A

Summary for 3MNP

• Entry DOI: 10.2210/pdb3mnp/pdb
• Related: 3MNE 3MNO
• Descriptor: Glucocorticoid receptor, Nuclear receptor coactivator 2 peptide, GLYCEROL, ... (6 entities in total)
• Functional Keywords: protein-ligand complex, steroid nuclear receptor, mouse gr, agonist, co-activator, hormone receptor
• Biological source: Mus musculus (mouse); More
• Cellular location: Cytoplasm: P06537; Nucleus: Q61026
• Total number of polymer chains: 2
• Total formula weight: 32370.78

Authors

Schoch, G.A.,Seitz, T.,Benz, J.,Banner, D.,Stihle, M.,D'Arcy, B.,Thoma, R.,Sterner, R.,Hennig, M.,Ruf, A. (deposition date: 2010-04-22, release date: 2010-09-15, Last modification date: 2023-09-06)

• Primary citation: Seitz, T.,Thoma, R.,Schoch, G.A.,Stihle, M.,Benz, J.,D'Arcy, B.,Wiget, A.,Ruf, A.,Hennig, M.,Sterner, R.; Enhancing the stability and solubility of the glucocorticoid receptor ligand-binding domain by high-throughput library screening.; J.Mol.Biol., 403:562-577, 2010; PubMed: 20850457; DOI: 10.1016/j.jmb.2010.08.048

Experimental method

X-RAY DIFFRACTION (1.5 Å)