3MNP
Crystal structure of the agonist form of mouse glucocorticoid receptor stabilized by (A611V, V708A, E711G) mutations at 1.50A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glucocorticoid receptor | polymer | 261 | 30084.1 | 1 | UniProt (P06537) Pfam (PF00104) | Mus musculus (mouse) | GR, Nuclear receptor subfamily 3 group C member 1 |
| 2 | B (B) | Nuclear receptor coactivator 2 peptide | polymer | 13 | 1593.8 | 1 | UniProt (Q61026) | NCoA-2, Transcriptional intermediary factor 2, Glucocorticoid receptor-interacting protein 1, GRIP-1 | |
| 3 | C, F (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) PubChem (753) | |||
| 4 | D (A) | DEXAMETHASONE | non-polymer | 392.5 | 1 | Chemie (DEX) PubChem (3003) PubChem (5743) PubChem (134645) PubChem (146915) PubChem (451600) PubChem (469455) PubChem (656865) PubChem (1150209) PubChem (1426961) PubChem (5702035) PubChem (6610297) PubChem (6610335) PubChem (6710614) PubChem (9830630) PubChem (9865316) PubChem (11014684) PubChem (12358596) PubChem (12358597) PubChem (12358599) PubChem (12358600) PubChem (12358601) PubChem (12358603) PubChem (14697793) PubChem (16757640) PubChem (21140858) PubChem (24758428) PubChem (24848023) PubChem (40467076) PubChem (40469527) PubChem (40469528) PubChem (40469529) PubChem (40469538) PubChem (40469540) PubChem (176476476) PubChem (176476477) PubChem (176481066) PubChem (176519880) PubChem (176541415) PubChem (46870667) PubChem (18609236) PubChem (40467075) PubChem (45791747) PubChem (51654720) PubChem (68625576) PubChem (176476478) PubChem (3036635) PubChem (9782) PubChem (155299) PubChem (71299643) PubChem (51529018) PubChem (969487) PubChem (51723203) PubChem (51723204) PubChem (53316140) PubChem (92043418) PubChem (92259599) PubChem (5702012) PubChem (6432476) PubChem (6546942) PubChem (6604243) PubChem (6603742) PubChem (56627169) PubChem (124301806) PubChem (57959704) PubChem (57959709) PubChem (59499751) PubChem (59553041) PubChem (60032782) PubChem (60107679) PubChem (60107685) PubChem (60113881) PubChem (60129028) PubChem (66739593) PubChem (67968282) PubChem (68163950) PubChem (68346426) PubChem (69301933) PubChem (70211292) PubChem (70834467) PubChem (70965822) PubChem (71083129) PubChem (73707402) PubChem (73945193) PubChem (73950719) PubChem (90141965) PubChem (92259552) PubChem (117072391) PubChem (123132537) PubChem (124190915) PubChem (124304345) PubChem (124904342) PubChem (124904343) PubChem (124918510) PubChem (124918511) PubChem (129010233) PubChem (133634290) PubChem (133645861) PubChem (134990893) PubChem (135396701) PubChem (137704752) PubChem (139404989) PubChem (140662068) PubChem (145705940) PubChem (146436354) PubChem (152964101) PubChem (162730335) PubChem (163285078) PubChem (163285103) PubChem (164010962) PubChem (175434953) PubChem (176282643) | |||
| 5 | E, G (A) | THIOCYANATE ION | non-polymer | 58.1 | 2 | Chemie (SCN) PubChem (9322) | |||
| 6 | H, I (A, B) | water | water | 18.0 | 377 | Chemie (HOH) |
Sequence modifications
A: 527 - 783 (UniProt: P06537)
| PDB | External Database | Details |
|---|---|---|
| Gly 523 | - | expression tag |
| Ser 524 | - | expression tag |
| His 525 | - | expression tag |
| Met 526 | - | expression tag |
| Val 611 | Ala 611 | engineered mutation |
| Ala 708 | Val 708 | engineered mutation |
| Gly 711 | Glu 711 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 31678.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 692.8 | |
| All* | Total formula weight | 32370.8 |
