3MNP
Crystal structure of the agonist form of mouse glucocorticoid receptor stabilized by (A611V, V708A, E711G) mutations at 1.50A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glucocorticoid receptor | polymer | 261 | 30084.1 | 1 | UniProt (P06537) Pfam (PF00104) | Mus musculus (mouse) | GR, Nuclear receptor subfamily 3 group C member 1 |
| 2 | B (B) | Nuclear receptor coactivator 2 peptide | polymer | 13 | 1593.8 | 1 | UniProt (Q61026) | NCoA-2, Transcriptional intermediary factor 2, Glucocorticoid receptor-interacting protein 1, GRIP-1 | |
| 3 | C, F (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 4 | D (A) | DEXAMETHASONE | non-polymer | 392.5 | 1 | Chemie (DEX) | |||
| 5 | E, G (A) | THIOCYANATE ION | non-polymer | 58.1 | 2 | Chemie (SCN) | |||
| 6 | H, I (A, B) | water | water | 18.0 | 377 | Chemie (HOH) |
Sequence modifications
A: 527 - 783 (UniProt: P06537)
| PDB | External Database | Details |
|---|---|---|
| Gly 523 | - | expression tag |
| Ser 524 | - | expression tag |
| His 525 | - | expression tag |
| Met 526 | - | expression tag |
| Val 611 | Ala 611 | engineered mutation |
| Ala 708 | Val 708 | engineered mutation |
| Gly 711 | Glu 711 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 31678.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 692.8 | |
| All* | Total formula weight | 32370.8 |
