3LMP
Crystal structure of the PPARgamma-LBD complexed with a cercosporamide derivative modulator
Summary for 3LMP
Entry DOI | 10.2210/pdb3lmp/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, Peptide of Nuclear receptor coactivator 1, (9aS)-8-acetyl-1,7-dihydroxy-3-methoxy-9a-methyl-N-(1-naphthylmethyl)-9-oxo-9,9a-dihydrodibenzo[b,d]furan-4-carboxamide, ... (4 entities in total) |
Functional Keywords | three-layered alpha-helical sandwich, activator, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, polymorphism, receptor, transcription, transcription regulation, zinc-finger |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P37231 Q15788 |
Total number of polymer chains | 2 |
Total formula weight | 34674.13 |
Authors | Matsui, Y.,Hanzawa, H. (deposition date: 2010-01-31, release date: 2010-04-14, Last modification date: 2023-11-01) |
Primary citation | Furukawa, A.,Arita, T.,Satoh, S.,Wakabayashi, K.,Hayashi, S.,Matsui, Y.,Araki, K.,Kuroha, M.,Ohsumi, J. Discovery of a novel selective PPARgamma modulator from (-)-Cercosporamide derivatives Bioorg.Med.Chem.Lett., 20:2095-2098, 2010 Cited by PubMed: 20219371DOI: 10.1016/j.bmcl.2010.02.073 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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