Crystal structure of the PPARgamma-LBD complexed with a cercosporamide derivative modulator

Summary for 3LMP

DescriptorPeroxisome proliferator-activated receptor gamma, Peptide of Nuclear receptor coactivator 1, (9aS)-8-acetyl-1,7-dihydroxy-3-methoxy-9a-methyl-N-(1-naphthylmethyl)-9-oxo-9,9a-dihydrodibenzo[b,d]furan-4-carboxamide, ... (4 entities in total)
Functional Keywordsthree-layered alpha-helical sandwich, activator, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, polymorphism, receptor, transcription, transcription regulation, zinc-finger
Biological sourceHomo sapiens (human)
Cellular locationNucleus P37231 Q15788
Total number of polymer chains2
Total molecular weight34674.13
Matsui, Y.,Hanzawa, H. (deposition date: 2010-01-31, release date: 2010-04-14, Last modification date: 2017-11-01)
Primary citation
Furukawa, A.,Arita, T.,Satoh, S.,Wakabayashi, K.,Hayashi, S.,Matsui, Y.,Araki, K.,Kuroha, M.,Ohsumi, J.
Discovery of a novel selective PPARgamma modulator from (-)-Cercosporamide derivatives
Bioorg.Med.Chem.Lett., 20:2095-2098, 2010
PubMed: 20219371 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2010.02.073
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2421301.2%9.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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