3ADW

Human PPARgamma ligand-binding domain in complex with 5-methoxy-indole acetate and 15-oxo-eicosatetraenoic acid

Summary for 3ADW

Related3ADS 3ADT 3ADU 3ADV 3ADX
DescriptorPeroxisome proliferator-activated receptor gamma, (5-methoxy-1H-indol-3-yl)acetic acid, (5E,8E,11Z,13E)-15-oxoicosa-5,8,11,13-tetraenoic acid, ... (4 entities in total)
Functional Keywordsnuclear receptor, ligand-dependent transcription factor, ligand-binding domain, activator, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, receptor, transcription, transcription regulation, zinc-finger
Biological sourceHomo sapiens (human)
Cellular locationNucleus P37231
Total number of polymer chains2
Total molecular weight66229.76
Authors
Waku, T.,Shiraki, T.,Oyama, T.,Morikawa, K. (deposition date: 2010-01-29, release date: 2010-12-22, Last modification date: 2011-07-13)
Primary citation
Waku, T.,Shiraki, T.,Oyama, T.,Maebara, K.,Nakamori, R.,Morikawa, K.
The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites
Embo J., 29:3395-3407, 2010
PubMed: 20717101 (PDB entries with the same primary citation)
DOI: 10.1038/emboj.2010.197
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.07 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.263202.9%3.8%13.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

Molmil generated image of 3adw
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Molmil generated image of 3adw
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Molmil generated image of 3adw
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3adw.pdb1.gz [91.03 KB])
Coordinate files for Biological unit (3adw.pdb2.gz [91.69 KB])