3ADX

Human PPARgamma ligand-binding domain in complex with indomethacin and nitro-233

Summary for 3ADX

Entry DOI	10.2210/pdb3adx/pdb
Related	3ADS 3ADT 3ADU 3ADV 3ADW
Descriptor	Peroxisome proliferator-activated receptor gamma, 3-[5-(2-nitropent-1-en-1-yl)furan-2-yl]benzoic acid, INDOMETHACIN, ... (4 entities in total)
Functional Keywords	nuclear receptor, ligand-dependent transcription factor, ligand-binding domain, activator, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, receptor, transcription, transcription regulation, zinc-finger
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P37231
Total number of polymer chains	2
Total formula weight	66404.52
Authors	Waku, T.,Shiraki, T.,Oyama, T.,Morikawa, K. (deposition date: 2010-01-29, release date: 2010-12-22, Last modification date: 2023-11-01)
Primary citation	Waku, T.,Shiraki, T.,Oyama, T.,Maebara, K.,Nakamori, R.,Morikawa, K. The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites Embo J., 29:3395-3407, 2010 Cited by PubMed: 20717101 DOI: 10.1038/emboj.2010.197 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation