3ADX
Human PPARgamma ligand-binding domain in complex with indomethacin and nitro-233
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Peroxisome proliferator-activated receptor gamma | polymer | 287 | 32693.8 | 2 | UniProt (P37231) Pfam (PF00104) | Homo sapiens (human) | PPAR-gamma, Nuclear receptor subfamily 1 group C member 3 |
| 2 | C (A) | 3-[5-(2-nitropent-1-en-1-yl)furan-2-yl]benzoic acid | non-polymer | 301.3 | 1 | Chemie (NRO) | |||
| 3 | D, E (A, B) | INDOMETHACIN | non-polymer | 357.8 | 2 | Chemie (IMN) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 71 | Chemie (HOH) |
Sequence modifications
A, B: 195 - 477 (UniProt: P37231)
| PDB | External Database | Details |
|---|---|---|
| Gly 191 | - | expression tag |
| Ser 192 | - | expression tag |
| His 193 | - | expression tag |
| Met 194 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65387.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1016.9 | |
| All* | Total formula weight | 66404.5 |
