3ADX

Human PPARgamma ligand-binding domain in complex with indomethacin and nitro-233

Summary for 3ADX

Related3ADS 3ADT 3ADU 3ADV 3ADW
DescriptorPeroxisome proliferator-activated receptor gamma, 3-[5-(2-nitropent-1-en-1-yl)furan-2-yl]benzoic acid, INDOMETHACIN, ... (4 entities in total)
Functional Keywordsnuclear receptor, ligand-dependent transcription factor, ligand-binding domain, activator, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, receptor, transcription, transcription regulation, zinc-finger
Biological sourceHomo sapiens (human)
Cellular locationNucleus P37231
Total number of polymer chains2
Total molecular weight66404.52
Authors
Waku, T.,Shiraki, T.,Oyama, T.,Morikawa, K. (deposition date: 2010-01-29, release date: 2010-12-22, Last modification date: 2011-07-13)
Primary citation
Waku, T.,Shiraki, T.,Oyama, T.,Maebara, K.,Nakamori, R.,Morikawa, K.
The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites
Embo J., 29:3395-3407, 2010
PubMed: 20717101 (PDB entries with the same primary citation)
DOI: 10.1038/emboj.2010.197
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.95 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.274162.5%4.7%13.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3adx
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Molmil generated image of 3adx
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Molmil generated image of 3adx
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More Biological unit images

Molmil generated image of 3adx
no rotation
Molmil generated image of 3adx
rotated about x axis by 90°
Molmil generated image of 3adx
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3adx.pdb2.gz [89.01 KB])
Coordinate files for Biological unit (3adx.pdb1.gz [88.46 KB])