3ADS

Human PPARgamma ligand-binding domain in complex with indomethacin

Summary for 3ADS

Related3ADT 3ADU 3ADV 3ADW 3ADX
DescriptorPeroxisome proliferator-activated receptor gamma, INDOMETHACIN (3 entities in total)
Functional Keywordsnuclear receptor, ligand-dependent transcription factor, ligand-binding domain, activator, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, receptor, transcription, transcription regulation, zinc-finger
Biological sourceHomo sapiens (human)
Cellular locationNucleus P37231
Total number of polymer chains2
Total molecular weight66461.01
Authors
Waku, T.,Shiraki, T.,Oyama, T.,Morikawa, K. (deposition date: 2010-01-29, release date: 2010-12-22, Last modification date: 2011-07-13)
Primary citation
Waku, T.,Shiraki, T.,Oyama, T.,Maebara, K.,Nakamori, R.,Morikawa, K.
The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites
Embo J., 29:3395-3407, 2010
PubMed: 20717101 (PDB entries with the same primary citation)
DOI: 10.1038/emboj.2010.197
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.25 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.275171.6%3.5%6.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report