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3ADS

Human PPARgamma ligand-binding domain in complex with indomethacin

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
B0003677molecular_functionDNA binding
B0004879molecular_functionnuclear receptor activity
B0005634cellular_componentnucleus
B0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE IMN A 1
ChainResidue
AARG280
AMET364
AGLY284
ACYS285
AARG288
ALEU330
ALEU340
AILE341
ASER342
AMET348

site_idAC2
Number of Residues15
DetailsBINDING SITE FOR RESIDUE IMN A 2
ChainResidue
AILE281
APHE282
ACYS285
ASER289
AHIS323
ATYR327
ALEU330
ALEU356
APHE360
APHE363
AMET364
AHIS449
ALEU453
ALEU469
ATYR473

site_idAC3
Number of Residues11
DetailsBINDING SITE FOR RESIDUE IMN B 3
ChainResidue
BILE281
BARG288
BSER289
BALA292
BILE326
BLEU330
BLEU333
BLEU340
BILE341
BGLU343
BMET364

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
ChainResidueDetails
AGLN286
AHIS323
AHIS449
ATYR473
BGLN286
BHIS323
BHIS449
BTYR473

site_idSWS_FT_FI2
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649
ChainResidueDetails
ALYS224
BLYS224

226707

PDB entries from 2024-10-30

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