3NOA

Crystal structure of human PPAR-gamma ligand binding domain complex with a potency improved agonist

Summary for 3NOA

DescriptorPeroxisome proliferator-activated receptor gamma, (5-{3-[4-(biphenyl-4-ylcarbonyl)-2-propylphenoxy]propoxy}-1H-indol-1-yl)acetic acid (3 entities in total)
Functional Keywordshypoglycemic agents, models, molecular, ppar alpha, ppar gamma, protein isoforms, quinolines, structure-activity relationship, thiazolidinediones, transcription
Biological sourceHomo sapiens (human)
Cellular locationNucleus P37231
Total number of polymer chains2
Total molecular weight63089.32
Authors
Peng, Y.H.,Wu, J.S.,Wu, S.Y. (deposition date: 2010-06-25, release date: 2011-06-29, Last modification date: 2011-07-13)
Primary citation
Peng, Y.H.,Coumar, M.S.,Leou, J.S.,Wu, J.S.,Shiao, H.Y.,Lin, C.H.,Lyu, P.C.,Hsieh, H.P.,Wu, S.Y.
Crystal structure of human PPAR-gamma ligand binding domain complex with a potency improved agonist
To be published,
Experimental method
X-RAY DIFFRACTION (1.98 Å)
NMR Information
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.27371.5%2.3%17.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report