3AFR

Crystal Structure of VDR-LBD/22S-Butyl-1a,24R-dihydroxyvitamin D3 complex

Summary for 3AFR

• Entry DOI: 10.2210/pdb3afr/pdb
• Related: 2ZXM 2ZXN
• Descriptor: Vitamin D3 receptor, 13-meric peptide from Mediator of RNA polymerase II transcription subunit 1, (1R,3S,5Z)-5-[(2E)-2-{(1R,3aS,7aR)-1-[(1R,2S,4R)-2-butyl-4-hydroxy-1,5-dimethylhexyl]-7a-methyloctahydro-4H-inden-4-yli dene}ethylidene]-4-methylidenecyclohexane-1,3-diol, ... (4 entities in total)
• Functional Keywords: vitamin d receptor, nuclear receptor, agonist, antagonist, vitamin d derivative, dna-binding, nucleus, receptor, transcription, transcription regulation, transcription-transcription regulator complex, transcription/transcription regulator
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Nucleus: P13053 A1L0Z0
• Total number of polymer chains: 2
• Total formula weight: 32638.68

Authors

Inaba, Y.,Nakabayashi, M.,Itoh, T.,Ikura, T.,Ito, N.,Yamamoto, K. (deposition date: 2010-03-10, release date: 2010-03-31, Last modification date: 2023-11-01)

• Primary citation: Inaba, Y.,Nakabayashi, M.,Itoh, T.,Yoshimoto, N.,Ikura, T.,Ito, N.,Shimizu, M.,Yamamoto, K.; 22S-Butyl-1alpha,24R-dihydroxyvitamin D(3): Recovery of vitamin D receptor agonistic activity; J.Steroid Biochem.Mol.Biol., 121:146-150, 2010; PubMed: 20211257; DOI: 10.1016/j.jsbmb.2010.02.033

Experimental method

X-RAY DIFFRACTION (2 Å)