3OAP

Crystal structure of human Retinoid X Receptor alpha-ligand binding domain complex with 9-cis retinoic acid and the coactivator peptide GRIP-1

Summary for 3OAP

• Entry DOI: 10.2210/pdb3oap/pdb
• Related: 1FBY
• Descriptor: Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, (9cis)-retinoic acid, ... (4 entities in total)
• Functional Keywords: antiparallel sandwich, ligand binding, coactivator binding, dimerization, activation function, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : P19793 Q15596
• Total number of polymer chains: 2
• Total formula weight: 27603.17

Authors

Xia, G.,Smith, C.D.,Muccio, D.D. (deposition date: 2010-08-05, release date: 2010-11-17, Last modification date: 2024-02-21)

• Primary citation: Xia, G.,Boerma, L.J.,Cox, B.D.,Qiu, C.,Kang, S.,Smith, C.D.,Renfrow, M.B.,Muccio, D.D.; Structure, Energetics and Dynamics of Binding Coactivator Peptide to Human Retinoid X Receptor Alpha Ligand Binding Domain Complex with 9-cis-Retinoic Acid.; Biochemistry, 50:93-105, 2011; PubMed: 21049972; DOI: 10.1021/bi101288y

Experimental method

X-RAY DIFFRACTION (2.05 Å)