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6OIJ
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Muscarinic acetylcholine receptor 1-G11 protein complex
分子名称: 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Antibody fragment, CHOLESTEROL HEMISUCCINATE, ...
著者Maeda, S, Qianhui, Q, Skiniotis, G, Kobilka, B.
登録日2019-04-09
公開日2019-05-08
最終更新日2020-01-08
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes.
Science, 364, 2019
8TH4
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Structure of AT118-L Nanobody Antagonist in Complex with the Angiotensin II Type I Receptor and Losartan
分子名称: AT118-L Nanobody, BAG2 Anti-BRIL Fab Heavy Chain, BAG2 Anti-BRIL Fab Light Chain, ...
著者Skiba, M.A, Kruse, A.C.
登録日2023-07-13
公開日2024-05-22
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Antibodies expand the scope of angiotensin receptor pharmacology.
Nat.Chem.Biol., 2024
7LD4
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Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist
分子名称: ADENOSINE, Chimera protein of Muscarinic acetylcholine receptor M4 and Adenosine receptor A1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Draper-Joyce, C.J, Danev, R, Thal, D.M, Christopoulos, A, Glukhova, A.
登録日2021-01-12
公開日2021-09-08
最終更新日2021-10-13
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Positive allosteric mechanisms of adenosine A 1 receptor-mediated analgesia.
Nature, 597, 2021
8GGN
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Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #6 of 20)
分子名称: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
著者Papasergi-Scott, M.M, Skiniotis, G.
登録日2023-03-08
公開日2024-03-06
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8GE2
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CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#3 of 20)
分子名称: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Papasergi-Scott, M.M, Skiniotis, G.
登録日2023-03-06
公開日2024-03-06
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
7CRH
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BU of 7crh by Molmil
Cryo-EM structure of SKF83959 bound dopamine receptor DRD1-Gs signaling complex
分子名称: (1S)-6-chloranyl-3-methyl-1-(3-methylphenyl)-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol, D(1A) dopamine receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Yan, W, Shao, Z.H.
登録日2020-08-13
公開日2021-03-03
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.
Cell, 184, 2021
7YIT
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Molecular mechanism of biased signaling at the kappa opioid receptor
分子名称: Kappa-type opioid receptor, Nanobody39, Soluble cytochrome b562, ...
著者Kim, K, Che, T.
登録日2022-07-18
公開日2023-04-12
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Molecular mechanism of biased signaling at the kappa opioid receptor.
Nat Commun, 14, 2023
6OYA
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BU of 6oya by Molmil
Structure of the Rhodopsin-Transducin-Nanobody Complex
分子名称: Camelid antibody VHH fragment, Gt-alpha/Gi1-alpha chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Gao, Y, Hu, H, Ramachandran, S, Erickson, J.W, Cerione, R.A, Skiniotis, G.
登録日2019-05-14
公開日2019-07-24
最終更新日2019-12-04
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation.
Mol.Cell, 75, 2019
6GPS
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CRYSTAL STRUCTURE OF CCR2A IN COMPLEX WITH MK-0812
分子名称: C-C chemokine receptor type 2,Rubredoxin,C-C chemokine receptor type 2, ZINC ION, [(3~{S},4~{S})-3-methoxyoxan-4-yl]-[(1~{R},3~{S})-3-propan-2-yl-3-[[3-(trifluoromethyl)-7,8-dihydro-5~{H}-1,6-naphthyridin-6-yl]carbonyl]cyclopentyl]azanium
著者Pautsch, A, Schnapp, G.
登録日2018-06-07
公開日2019-01-02
最終更新日2019-03-13
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Crystal Structure of CC Chemokine Receptor 2A in Complex with an Orthosteric Antagonist Provides Insights for the Design of Selective Antagonists.
Structure, 27, 2019
4BEZ
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BU of 4bez by Molmil
Night blindness causing G90D rhodopsin in the active conformation
分子名称: ACETATE ION, PALMITIC ACID, RHODOPSIN, ...
著者Singhal, A, Ostermaier, M.K, Vishnivetskiy, S.A, Panneels, V, Homan, K.T, Tesmer, J.J.G, Veprintsev, D, Deupi, X, Gurevich, V.V, Schertler, G.F.X, Standfuss, J.
登録日2013-03-12
公開日2013-04-24
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Insights Into Congenital Stationary Night Blindness Based on the Structure of G90D Rhodopsin.
Embo Rep., 14, 2013
7Y1F
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BU of 7y1f by Molmil
Cryo-EM structure of human k-opioid receptor-Gi complex
分子名称: Dynorphin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Chen, B.O, Xu, F.E.
登録日2022-06-08
公開日2023-05-24
最終更新日2023-06-21
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Cryo-EM structure of human kappa-opioid receptor-Gi complex bound to an endogenous agonist dynorphin A.
Protein Cell, 14, 2023
4A4M
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BU of 4a4m by Molmil
Crystal structure of the light-activated constitutively active N2C, M257Y,D282C rhodopsin mutant in complex with a peptide resembling the C-terminus of the Galpha-protein subunit (GaCT)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, GUANINE NUCLEOTIDE-BINDING PROTEIN G(T) SUBUNIT ALPHA-3, ...
著者Deupi, X, Edwards, P, Singhal, A, Nickle, B, Oprian, D.D, Schertler, G.F.X, Standfuss, J.
登録日2011-10-17
公開日2012-01-25
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Stabilized G Protein Binding Site in the Structure of Constitutively Active Metarhodopsin-II.
Proc.Natl.Acad.Sci.USA, 109, 2012
7WVU
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BU of 7wvu by Molmil
Cryo-EM structure of the human formyl peptide receptor 1 in complex with fMLF and Gi1
分子名称: FME-LEU-PHE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B.
登録日2022-02-11
公開日2022-04-13
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
7D7M
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BU of 7d7m by Molmil
Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein
分子名称: (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Nojima, S, Fujita, Y, Kimura, T.K, Nomura, N, Suno, R, Morimoto, K, Yamamoto, M, Noda, T, Iwata, S, Shigematsu, H, Kobayashi, T.
登録日2020-10-05
公開日2020-11-18
最終更新日2021-03-17
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein.
Structure, 29, 2021
7YU5
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BU of 7yu5 by Molmil
Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, state1
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者Akasaka, H, Shihoya, W, Nureki, O.
登録日2022-08-16
公開日2022-10-05
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structure of the active G i -coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist.
Nat Commun, 13, 2022
7YU4
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Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, focused on receptor
分子名称: Lysophosphatidic acid receptor 1, [(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate
著者Akasaka, H, Shihoya, W, Nureki, O.
登録日2022-08-16
公開日2022-10-05
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structure of the active G i -coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist.
Nat Commun, 13, 2022
6KO5
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BU of 6ko5 by Molmil
Complex structure of Ghrelin receptor with Fab
分子名称: 6-(4-bromanyl-2-fluoranyl-phenoxy)-2-methyl-3-[[(3~{S})-1-propan-2-ylpiperidin-3-yl]methyl]pyrido[3,2-d]pyrimidin-4-one, Chimera of Soluble cytochrome b562 and Growth hormone secretagogue receptor type 1, Fab7881 Heavy Chain, ...
著者Shiimura, Y, Horita, S, Asada, H, Hirata, K, Iwata, S, Kojima, M.
登録日2019-08-08
公開日2020-08-12
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode.
Nat Commun, 11, 2020
4ZWJ
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BU of 4zwj by Molmil
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
分子名称: Chimera protein of human Rhodopsin, mouse S-arrestin, and T4 Endolysin
著者Kang, Y, Zhou, X.E, Gao, X, He, Y, Liu, W, Ishchenko, A, Barty, A, White, T.A, Yefanov, O, Han, G.W, Xu, Q, de Waal, P.W, Ke, J, Tan, M.H.E, Zhang, C, Moeller, A, West, G.M, Pascal, B, Eps, N.V, Caro, L.N, Vishnivetskiy, S.A, Lee, R.J, Suino-Powell, K.M, Gu, X, Pal, K, Ma, J, Zhi, X, Boutet, S, Williams, G.J, Messerschmidt, M, Gati, C, Zatsepin, N.A, Wang, D, James, D, Basu, S, Roy-Chowdhury, S, Conrad, C, Coe, J, Liu, H, Lisova, S, Kupitz, C, Grotjohann, I, Fromme, R, Jiang, Y, Tan, M, Yang, H, Li, J, Wang, M, Zheng, Z, Li, D, Howe, N, Zhao, Y, Standfuss, J, Diederichs, K, Dong, Y, Potter, C.S, Carragher, B, Caffrey, M, Jiang, H, Chapman, H.N, Spence, J.C.H, Fromme, P, Weierstall, U, Ernst, O.P, Katritch, V, Gurevich, V.V, Griffin, P.R, Hubbell, W.L, Stevens, R.C, Cherezov, V, Melcher, K, Xu, H.E, GPCR Network (GPCR)
登録日2015-05-19
公開日2015-07-29
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.302 Å)
主引用文献Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser.
Nature, 523, 2015
5N2S
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BU of 5n2s by Molmil
Crystal structure of stabilized A1 receptor in complex with PSB36 at 3.3A resolution
分子名称: 1-butyl-3-(3-oxidanylpropyl)-8-[(1~{R},5~{S})-3-tricyclo[3.3.1.0^{3,7}]nonanyl]-7~{H}-purine-2,6-dione, SULFATE ION, Soluble cytochrome b562,Adenosine receptor A1
著者Cheng, R.K.Y, Segala, E, Robertson, N, Deflorian, F, Dore, A.S, Errey, J.C, Fiez-Vandal, C, Marshall, F.H, Cooke, R.M.
登録日2017-02-08
公開日2017-07-26
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.303 Å)
主引用文献Structures of Human A1 and A2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity.
Structure, 25, 2017
3REY
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BU of 3rey by Molmil
Thermostabilised adenosine A2A receptor in complex with XAC
分子名称: Adenosine receptor A2a, N-(2-aminoethyl)-2-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)phenoxy]acetamide
著者Dore, A.S, Robertson, N, Errey, J.C, Ng, I, Hollenstein, K, Tehan, B, Hurrell, E, Bennett, K, Congreve, M, Magnani, F, Tate, C.G, Weir, M, Marshall, F.H.
登録日2011-04-05
公開日2011-09-07
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.309 Å)
主引用文献Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine
Structure, 19, 2011
8UH3
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Serotonin 1E receptor (5-HT1eR)-Gi1 Complex bound with Setiptiline
分子名称: 5-hydroxytryptamine receptor 1E, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Wacker, D, Parpounas, A.K, Warren, A.L, Zilberg, G.
登録日2023-10-06
公開日2024-05-01
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3.31 Å)
主引用文献Structural insights into the unexpected agonism of tetracyclic antidepressants at serotonin receptors 5-HT 1e R and 5-HT 1F R.
Sci Adv, 10, 2024
8UGY
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Serotonin 1E receptor (5-HT1eR)-Gi1 Complex bound with Mianserin
分子名称: 5-hydroxytryptamine receptor 1E, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Zilberg, G, Warren, A.L, Wacker, D.
登録日2023-10-06
公開日2024-05-01
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3.31 Å)
主引用文献Structural insights into the unexpected agonism of tetracyclic antidepressants at serotonin receptors 5-HT 1e R and 5-HT 1F R.
Sci Adv, 10, 2024
8ZR5
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Cryo-EM Structure of GPR119-Gs-Firuglipel complex
分子名称: 4-[5-[(1~{R})-1-(4-cyclopropylcarbonylphenoxy)propyl]-1,2,4-oxadiazol-3-yl]-2-fluoranyl-~{N}-[(2~{R})-1-oxidanylpropan-2-yl]benzamide, Glucose-dependent insulinotropic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Wong, T.S, Zeng, Z.C, Xiong, T.T, Gan, S.Y, Qiu, C, Du, Y.
登録日2024-06-04
公開日2024-06-19
実験手法ELECTRON MICROSCOPY (3.31 Å)
主引用文献Cryo-EM structure of GPR119-Gs complex
To Be Published
8JZZ
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Structure of human C5a-desArg bound human C5aR1 in complex with Go
分子名称: Antibody fragment ScFv16, C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, ...
著者Yadav, M.K, Yadav, R, Maharana, J, Sarma, P, Banerjee, R, Shukla, A.K, Gati, C.
登録日2023-07-06
公開日2023-10-18
最終更新日2023-11-08
実験手法ELECTRON MICROSCOPY (3.31 Å)
主引用文献Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors.
Cell, 186, 2023
6LI3
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cryo-EM structure of GPR52-miniGs-NB35
分子名称: G-protein coupled receptor 52, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Li, M, Wang, N, Xu, F, Wu, J, Lei, M.
登録日2019-12-10
公開日2020-02-26
最終更新日2020-03-18
実験手法ELECTRON MICROSCOPY (3.32 Å)
主引用文献Structural basis of ligand recognition and self-activation of orphan GPR52.
Nature, 579, 2020

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