8GY7

Cryo-EM structure of ACTH-bound melanocortin-2 receptor in complex with MRAP1 and Gs protein

Summary for 8GY7

• Entry DOI: 10.2210/pdb8gy7/pdb
• EMDB information: 34371
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-3,Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• Functional Keywords: melanocortin-2 receptor, mrap1, gpcr, acth, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 180141.73

Authors

Luo, P.,Feng, W.B.,Ma, S.S.,Dai, A.T.,Yuan, Q.N.,Wu, K.,Yang, D.H.,Wang, M.W.,Xu, H.E.,Jiang, Y. (deposition date: 2022-09-21, release date: 2023-01-11)

• Primary citation: Luo, P.,Feng, W.,Ma, S.,Dai, A.,Wu, K.,Chen, X.,Yuan, Q.,Cai, X.,Yang, D.,Wang, M.W.,Eric Xu, H.,Jiang, Y.; Structural basis of signaling regulation of the human melanocortin-2 receptor by MRAP1.; Cell Res., 33:46-54, 2023; PubMed: 36588120; DOI: 10.1038/s41422-022-00751-6

Experimental method

ELECTRON MICROSCOPY (3.3 Å)