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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8GY7

Cryo-EM structure of ACTH-bound melanocortin-2 receptor in complex with MRAP1 and Gs protein

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Guanine nucleotide-binding protein G(i) subunit alpha-3,Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLaspolymer36141879.51UniProt (P08754)
UniProt (Q5JWF2)
Pfam (PF00503)		Homo sapiens (human)G(i) alpha-3,Adenylate cyclase-stimulating G alpha protein,Extra large alphas protein,XLalphas
2B
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer37140227.01UniProt (P62873)
Pfam (PF25391)		Homo sapiens (human)Transducin beta chain 1
3C
(G)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)		Homo sapiens (human)G gamma-I
4D
(M)		Corticotropinpolymer182256.71UniProt (P68000)synthetic constructAdrenocorticotropic hormone,ACTH
5E
(P)		Melanocortin-2 receptor accessory proteinpolymer18420486.21UniProt (Q8TCY5)
Pfam (PF15183)		Homo sapiens (human)B27,Fat cell-specific low molecular weight protein,Fat tissue-specific low MW protein
6F
(R)		Soluble cytochrome b562,Adrenocorticotropic hormone receptor,melanocortin-2 receptor,Adrenocorticotropic hormone receptor,Adrenocorticotropic hormone receptorpolymer60167391.21UniProt (P0ABE7)
UniProt (Q01718)
Pfam (PF00001)		Homo sapiens (human)Cytochrome b-562,ACTH receptor,ACTH-R,Adrenocorticotropin receptor,Melanocortin receptor 2,MC2-R
7G
(R)		CALCIUM IONnon-polymer40.11Chemie (CA)
Sequence modifications
A: 1 - 230 (UniProt: P08754)
PDBExternal DatabaseDetails
Glu 20Asp 20conflict
Lys 21Arg 21conflict
Gln 22Asn 22conflict
Gln 24Arg 24conflict
Lys 25Glu 25conflict
Lys 27Gly 27conflict
Gln 28Glu 28conflict
Val 29Lys 29conflict
Tyr 30Ala 30conflict
Arg 31Ala 31conflict
Ala 32Lys 32conflict
Thr 33Glu 33conflict
His 34Val 34conflict
Arg 35Lys 35conflict
Asp 42Gly 42conflict
Asn 43Glu 43conflict
Arg 54Lys 54conflict
Tyr 56Ile 56conflict
Val 58Glu 58conflict
Asn 59Asp 59conflict
Glu 64Asp 64conflict
Ala 71Val 71conflict
Asp 97Glu 97conflict
Ser 98Ala 98conflict
Ala 113Ser 113conflict
Phe 118Val 118conflict
Ala 121Pro 121conflict
Lys 132Arg 132conflict
Ser 134Gly 134conflict
Asn 141Ser 141conflict
Ala 153Ser 153conflict
Ala 163Ser 163conflict
Pro 165Ser 165conflict
Ser 182Thr 182conflict
Phe 185Val 185conflict
Lys 188His 188conflict
Gln 190Thr 190conflict
Val 191Phe 191conflict
Asp 192Lys 192conflict
Lys 193Asp 193conflict
Val 194Leu 194conflict
Asn 195Tyr 195conflict
His 197Lys 197conflict
Ala 203Gly 203conflict
Asp 206Ser 206conflict
Arg 209Lys 209conflict
Gln 213His 213conflict
Asn 216Glu 216conflict
Asp 217Gly 217conflict
Val 224Cys 224conflict
Asp 226Ala 226conflict
Ser 227Leu 227conflict
A: 231 - 361 (UniProt: Q5JWF2)
PDBExternal DatabaseDetails
Asp 239Leu 915conflict
Ser 333Ala 1009conflict
Ala 339Ile 1015conflict
Ile 342Val 1018conflict
B: 7 - 345 (UniProt: P62873)
PDBExternal DatabaseDetails
Met 1-initiating methionine
Gly 2-expression tag
Ser 3-expression tag
Leu 4-expression tag
Leu 5-expression tag
Gln 6-expression tag
Gly 346-expression tag
Ser 347-expression tag
Ser 348-expression tag
Gly 349-expression tag
Gly 350-expression tag
Gly 351-expression tag
Gly 352-expression tag
Ser 353-expression tag
Gly 354-expression tag
Gly 355-expression tag
Gly 356-expression tag
Gly 357-expression tag
Ser 358-expression tag
Ser 359-expression tag
Gly 360-expression tag
Val 361-expression tag
Ser 362-expression tag
Gly 363-expression tag
Trp 364-expression tag
Arg 365-expression tag
Leu 366-expression tag
Phe 367-expression tag
Lys 368-expression tag
Lys 369-expression tag
Ile 370-expression tag
Ser 371-expression tag
P: 1 - 172 (UniProt: Q8TCY5)
PDBExternal DatabaseDetails
Met -11-initiating methionine
Asp -10-expression tag
Tyr -9-expression tag
Lys -8-expression tag
Asp -7-expression tag
Asp -6-expression tag
Asp -5-expression tag
Asp -4-expression tag
Lys -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
Gly 0-expression tag
R: -104 - 1 (UniProt: P0ABE7)
PDBExternal DatabaseDetails
Met -130-initiating methionine
Lys -129-expression tag
Thr -128-expression tag
Ile -127-expression tag
Ile -126-expression tag
Ala -125-expression tag
Leu -124-expression tag
Ser -123-expression tag
Tyr -122-expression tag
Ile -121-expression tag
Phe -120-expression tag
Cys -119-expression tag
Leu -118-expression tag
Val -117-expression tag
Phe -116-expression tag
Ala -115-expression tag
His -114-expression tag
His -113-expression tag
His -112-expression tag
His -111-expression tag
His -110-expression tag
His -109-expression tag
His -108-expression tag
His -107-expression tag
His -106-expression tag
His -105-expression tag
Trp -98Met 29conflict
Ile -3His 124conflict
Leu 1Arg 128conflict
R: 2 - 297 (UniProt: Q01718)
R: 298 - 470 (PDB: 8GY7)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight180101.7
Non-Polymers*Number of molecules1
Total formula weight40.1
All*Total formula weight180141.7
*Water molecules are not included.

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PDB entries from 2026-01-21

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