8GY7
Cryo-EM structure of ACTH-bound melanocortin-2 receptor in complex with MRAP1 and Gs protein
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(i) subunit alpha-3,Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas | polymer | 361 | 41879.5 | 1 | UniProt (P08754) UniProt (Q5JWF2) Pfam (PF00503) In PDB | Homo sapiens (human) | G(i) alpha-3,Adenylate cyclase-stimulating G alpha protein,Extra large alphas protein,XLalphas |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 371 | 40227.0 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
4 | M | Corticotropin | polymer | 18 | 2256.7 | 1 | UniProt (P68000) Pfam (PF00976) In PDB | synthetic construct | Adrenocorticotropic hormone,ACTH |
5 | P | Melanocortin-2 receptor accessory protein | polymer | 184 | 20486.2 | 1 | UniProt (Q8TCY5) Pfam (PF15183) In PDB | Homo sapiens (human) | B27,Fat cell-specific low molecular weight protein,Fat tissue-specific low MW protein |
6 | R | Soluble cytochrome b562,Adrenocorticotropic hormone receptor,melanocortin-2 receptor,Adrenocorticotropic hormone receptor,Adrenocorticotropic hormone receptor | polymer | 601 | 67391.2 | 1 | UniProt (P0ABE7) UniProt (Q01718) Pfam (PF07361) Pfam (PF00001) In PDB | Homo sapiens (human) | Cytochrome b-562,ACTH receptor,ACTH-R,Adrenocorticotropin receptor,Melanocortin receptor 2,MC2-R |
7 | R | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) |
Sequence modifications
A: 1 - 230 (UniProt: P08754)
A: 231 - 361 (UniProt: Q5JWF2)
B: 7 - 345 (UniProt: P62873)
P: 1 - 172 (UniProt: Q8TCY5)
R: -104 - 1 (UniProt: P0ABE7)
R: 2 - 297 (UniProt: Q01718)
R: 298 - 470 (PDB: 8GY7)
PDB | External Database | Details |
---|---|---|
Glu 20 | Asp 20 | conflict |
Lys 21 | Arg 21 | conflict |
Gln 22 | Asn 22 | conflict |
Gln 24 | Arg 24 | conflict |
Lys 25 | Glu 25 | conflict |
Lys 27 | Gly 27 | conflict |
Gln 28 | Glu 28 | conflict |
Val 29 | Lys 29 | conflict |
Tyr 30 | Ala 30 | conflict |
Arg 31 | Ala 31 | conflict |
Ala 32 | Lys 32 | conflict |
Thr 33 | Glu 33 | conflict |
His 34 | Val 34 | conflict |
Arg 35 | Lys 35 | conflict |
Asp 42 | Gly 42 | conflict |
Asn 43 | Glu 43 | conflict |
Arg 54 | Lys 54 | conflict |
Tyr 56 | Ile 56 | conflict |
Val 58 | Glu 58 | conflict |
Asn 59 | Asp 59 | conflict |
Glu 64 | Asp 64 | conflict |
Ala 71 | Val 71 | conflict |
Asp 97 | Glu 97 | conflict |
Ser 98 | Ala 98 | conflict |
Ala 113 | Ser 113 | conflict |
Phe 118 | Val 118 | conflict |
Ala 121 | Pro 121 | conflict |
Lys 132 | Arg 132 | conflict |
Ser 134 | Gly 134 | conflict |
Asn 141 | Ser 141 | conflict |
Ala 153 | Ser 153 | conflict |
Ala 163 | Ser 163 | conflict |
Pro 165 | Ser 165 | conflict |
Ser 182 | Thr 182 | conflict |
Phe 185 | Val 185 | conflict |
Lys 188 | His 188 | conflict |
Gln 190 | Thr 190 | conflict |
Val 191 | Phe 191 | conflict |
Asp 192 | Lys 192 | conflict |
Lys 193 | Asp 193 | conflict |
Val 194 | Leu 194 | conflict |
Asn 195 | Tyr 195 | conflict |
His 197 | Lys 197 | conflict |
Ala 203 | Gly 203 | conflict |
Asp 206 | Ser 206 | conflict |
Arg 209 | Lys 209 | conflict |
Gln 213 | His 213 | conflict |
Asn 216 | Glu 216 | conflict |
Asp 217 | Gly 217 | conflict |
Val 224 | Cys 224 | conflict |
Asp 226 | Ala 226 | conflict |
Ser 227 | Leu 227 | conflict |
PDB | External Database | Details |
---|---|---|
Asp 239 | Leu 915 | conflict |
Ser 333 | Ala 1009 | conflict |
Ala 339 | Ile 1015 | conflict |
Ile 342 | Val 1018 | conflict |
PDB | External Database | Details |
---|---|---|
Met 1 | - | initiating methionine |
Gly 2 | - | expression tag |
Ser 3 | - | expression tag |
Leu 4 | - | expression tag |
Leu 5 | - | expression tag |
Gln 6 | - | expression tag |
Gly 346 | - | expression tag |
Ser 347 | - | expression tag |
Ser 348 | - | expression tag |
Gly 349 | - | expression tag |
Gly 350 | - | expression tag |
Gly 351 | - | expression tag |
Gly 352 | - | expression tag |
Ser 353 | - | expression tag |
Gly 354 | - | expression tag |
Gly 355 | - | expression tag |
Gly 356 | - | expression tag |
Gly 357 | - | expression tag |
Ser 358 | - | expression tag |
Ser 359 | - | expression tag |
Gly 360 | - | expression tag |
Val 361 | - | expression tag |
Ser 362 | - | expression tag |
Gly 363 | - | expression tag |
Trp 364 | - | expression tag |
Arg 365 | - | expression tag |
Leu 366 | - | expression tag |
Phe 367 | - | expression tag |
Lys 368 | - | expression tag |
Lys 369 | - | expression tag |
Ile 370 | - | expression tag |
Ser 371 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -11 | - | initiating methionine |
Asp -10 | - | expression tag |
Tyr -9 | - | expression tag |
Lys -8 | - | expression tag |
Asp -7 | - | expression tag |
Asp -6 | - | expression tag |
Asp -5 | - | expression tag |
Asp -4 | - | expression tag |
Lys -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Gly 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -130 | - | initiating methionine |
Lys -129 | - | expression tag |
Thr -128 | - | expression tag |
Ile -127 | - | expression tag |
Ile -126 | - | expression tag |
Ala -125 | - | expression tag |
Leu -124 | - | expression tag |
Ser -123 | - | expression tag |
Tyr -122 | - | expression tag |
Ile -121 | - | expression tag |
Phe -120 | - | expression tag |
Cys -119 | - | expression tag |
Leu -118 | - | expression tag |
Val -117 | - | expression tag |
Phe -116 | - | expression tag |
Ala -115 | - | expression tag |
His -114 | - | expression tag |
His -113 | - | expression tag |
His -112 | - | expression tag |
His -111 | - | expression tag |
His -110 | - | expression tag |
His -109 | - | expression tag |
His -108 | - | expression tag |
His -107 | - | expression tag |
His -106 | - | expression tag |
His -105 | - | expression tag |
Trp -98 | Met 29 | conflict |
Ile -3 | His 124 | conflict |
Leu 1 | Arg 128 | conflict |
R: 298 - 470 (PDB: 8GY7)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 180101.7 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 40.1 | |
All* | Total formula weight | 180141.7 |