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8GY7

Cryo-EM structure of ACTH-bound melanocortin-2 receptor in complex with MRAP1 and Gs protein

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0007186biological_processG protein-coupled receptor signaling pathway
A0019001molecular_functionguanyl nucleotide binding
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0048144biological_processfibroblast proliferation
G0070062cellular_componentextracellular exosome
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
M0005179molecular_functionhormone activity
M0005576cellular_componentextracellular region
P0005515molecular_functionprotein binding
P0005783cellular_componentendoplasmic reticulum
P0005789cellular_componentendoplasmic reticulum membrane
P0005886cellular_componentplasma membrane
P0030545molecular_functionsignaling receptor regulator activity
P0031780molecular_functioncorticotropin hormone receptor binding
P0031781molecular_functiontype 3 melanocortin receptor binding
P0031782molecular_functiontype 4 melanocortin receptor binding
P0031783molecular_functiontype 5 melanocortin receptor binding
P0042802molecular_functionidentical protein binding
P0043231cellular_componentintracellular membrane-bounded organelle
P0070996molecular_functiontype 1 melanocortin receptor binding
P0072659biological_processprotein localization to plasma membrane
P0106070biological_processregulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
P0106071biological_processpositive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
P0106072biological_processnegative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
P1903077biological_processnegative regulation of protein localization to plasma membrane
R0004930molecular_functionG protein-coupled receptor activity
R0004977molecular_functionmelanocortin receptor activity
R0004978molecular_functioncorticotropin receptor activity
R0005506molecular_functioniron ion binding
R0005515molecular_functionprotein binding
R0005737cellular_componentcytoplasm
R0005886cellular_componentplasma membrane
R0007186biological_processG protein-coupled receptor signaling pathway
R0007187biological_processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
R0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
R0007218biological_processneuropeptide signaling pathway
R0009055molecular_functionelectron transfer activity
R0016020cellular_componentmembrane
R0019222biological_processregulation of metabolic process
R0020037molecular_functionheme binding
R0022900biological_processelectron transport chain
R0042597cellular_componentperiplasmic space
R0046872molecular_functionmetal ion binding
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. GSIfSLSVIAADRYItI
ChainResidueDetails
RGLY116-ILE132

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU75-SER89
BILE162-ILE176
BLEU290-ALA304
BVAL332-GLY346

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: axial binding residue
ChainResidueDetails
RTRP-98
RILE-3

site_idSWS_FT_FI2
Number of Residues25
DetailsTRANSMEM: Helical; Name=1 => ECO:0000250
ChainResidueDetails
RVAL24-VAL49
AGLY40
ASER333

site_idSWS_FT_FI3
Number of Residues63
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250
ChainResidueDetails
RPHE50-PRO58
RASP127-THR147
RALA200-GLY217
RARG279-TRP297

site_idSWS_FT_FI4
Number of Residues20
DetailsTRANSMEM: Helical; Name=2 => ECO:0000250
ChainResidueDetails
RMET59-LEU79

site_idSWS_FT_FI5
Number of Residues46
DetailsTOPO_DOM: Extracellular => ECO:0000250
ChainResidueDetails
RGLU80-ASP104
RSER169-SER180
RCYS245-SER256

site_idSWS_FT_FI6
Number of Residues21
DetailsTRANSMEM: Helical; Name=3 => ECO:0000250
ChainResidueDetails
RILE105-ALA126

site_idSWS_FT_FI7
Number of Residues20
DetailsTRANSMEM: Helical; Name=4 => ECO:0000250
ChainResidueDetails
RVAL148-PHE168

site_idSWS_FT_FI8
Number of Residues18
DetailsTRANSMEM: Helical; Name=5 => ECO:0000250
ChainResidueDetails
RLEU181-LEU199

site_idSWS_FT_FI9
Number of Residues26
DetailsTRANSMEM: Helical; Name=6 => ECO:0000250
ChainResidueDetails
RALA218-PHE244

site_idSWS_FT_FI10
Number of Residues21
DetailsTRANSMEM: Helical; Name=7 => ECO:0000250
ChainResidueDetails
RLEU257-PHE278

site_idSWS_FT_FI11
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000255
ChainResidueDetails
RCYS293

site_idSWS_FT_FI12
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN12
RASN17

222926

PDB entries from 2024-07-24

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