8EF5

Fentanyl-bound mu-opioid receptor-Gi complex

Summary for 8EF5

• Entry DOI: 10.2210/pdb8ef5/pdb
• EMDB information: 28066 28069 28077 28085 28086 28088
• Descriptor: Mu-type opioid receptor, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (7 entities in total)
• Functional Keywords: mu-opioid receptor, g protein, fentanyl, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 7
• Total formula weight: 240566.89

Authors

Zhuang, Y.,Wang, Y.,Guo, S.,Zhou, X.E.,Rao, Q.,He, X.,He, B.,Liu, J.,Zhou, Q.,Wang, X.,Liu, W.,Jiang, X.,Yang, D.,Chen, X.,Jiang, Y.,Jiang, H.,Shen, J.,Melcher, K.,Wang, M.,Xie, X.,Xu, H.E. (deposition date: 2022-09-08, release date: 2022-11-09, Last modification date: 2022-11-30)

• Primary citation: Zhuang, Y.,Wang, Y.,He, B.,He, X.,Zhou, X.E.,Guo, S.,Rao, Q.,Yang, J.,Liu, J.,Zhou, Q.,Wang, X.,Liu, M.,Liu, W.,Jiang, X.,Yang, D.,Jiang, H.,Shen, J.,Melcher, K.,Chen, H.,Jiang, Y.,Cheng, X.,Wang, M.W.,Xie, X.,Xu, H.E.; Molecular recognition of morphine and fentanyl by the human mu-opioid receptor.; Cell, 185:4361-4375.e19, 2022; PubMed: 36368306; DOI: 10.1016/j.cell.2022.09.041

Experimental method

ELECTRON MICROSCOPY (3.3 Å)