6PT3

Crystal structure of the active delta opioid receptor in complex with the small molecule agonist DPI-287

Summary for 6PT3

Entry DOI	10.2210/pdb6pt3/pdb
Descriptor	Delta opioid receptor, 4-[(R)-[(2S,5R)-4-benzyl-2,5-dimethylpiperazin-1-yl](3-hydroxyphenyl)methyl]-N,N-diethylbenzamide (2 entities in total)
Functional Keywords	membrane protein, g protein-coupled receptor, gpcr, dop, dor, agonist, active dop-dpi-287 structure, lcp, membrane protein-agonist complex, membrane protein/agonist
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	103089.52
Authors	Claff, T.,Yu, J.,Blais, V.,Patel, N.,Martin, C.,Wu, L.,Han, G.W.,Holleran, B.J.,Van der Poorten, O.,Hanson, M.A.,Sarret, P.,Gendron, L.,Cherezov, V.,Katritch, V.,Ballet, S.,Liu, Z.,Muller, C.E.,Stevens, R.C. (deposition date: 2019-07-14, release date: 2019-12-11, Last modification date: 2023-10-11)
Primary citation	Claff, T.,Yu, J.,Blais, V.,Patel, N.,Martin, C.,Wu, L.,Han, G.W.,Holleran, B.J.,Van der Poorten, O.,White, K.L.,Hanson, M.A.,Sarret, P.,Gendron, L.,Cherezov, V.,Katritch, V.,Ballet, S.,Liu, Z.J.,Muller, C.E.,Stevens, R.C. Elucidating the active delta-opioid receptor crystal structure with peptide and small-molecule agonists. Sci Adv, 5:eaax9115-eaax9115, 2019 Cited by PubMed: 31807708 DOI: 10.1126/sciadv.aax9115 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation