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6PT3

Crystal structure of the active delta opioid receptor in complex with the small molecule agonist DPI-287

Functional Information from GO Data
ChainGOidnamespacecontents
A0004930molecular_functionG protein-coupled receptor activity
A0004985molecular_functionG protein-coupled opioid receptor activity
A0005506molecular_functioniron ion binding
A0007186biological_processG protein-coupled receptor signaling pathway
A0009055molecular_functionelectron transfer activity
A0016020cellular_componentmembrane
A0020037molecular_functionheme binding
A0022900biological_processelectron transport chain
A0038046molecular_functionG protein-coupled enkephalin receptor activity
A0042597cellular_componentperiplasmic space
B0004930molecular_functionG protein-coupled receptor activity
B0004985molecular_functionG protein-coupled opioid receptor activity
B0005506molecular_functioniron ion binding
B0007186biological_processG protein-coupled receptor signaling pathway
B0009055molecular_functionelectron transfer activity
B0016020cellular_componentmembrane
B0020037molecular_functionheme binding
B0022900biological_processelectron transport chain
B0038046molecular_functionG protein-coupled enkephalin receptor activity
B0042597cellular_componentperiplasmic space
Functional Information from PDB Data
site_idAC1
Number of Residues16
Detailsbinding site for residue OWY A 1201
ChainResidue
AALA98
AVAL281
ATRP284
ALEU300
AILE304
AGLY307
ATYR308
ASER311
AASP128
ASER131
AMET132
ALYS214
AVAL217
ATRP274
AILE277
AHIS278

site_idAC2
Number of Residues14
Detailsbinding site for residue OWY B 1201
ChainResidue
BALA98
BASP128
BSER131
BMET132
BLYS214
BVAL217
BTRP274
BILE277
BHIS278
BTRP284
BLEU300
BILE304
BGLY307
BSER311

Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. TSIfTLTMMCVDRYIaV
ChainResidueDetails
ATHR134-VAL150

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues54
DetailsTRANSMEM: Helical; Name=1 => ECO:0000250
ChainResidueDetails
ALEU48-VAL75
BLEU48-VAL75

site_idSWS_FT_FI2
Number of Residues98
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250
ChainResidueDetails
AARG76-ASN85
AASP145-ALA163
AARG239-ARG261
BARG76-ASN85
BASP145-ALA163
BARG239-ARG261

site_idSWS_FT_FI3
Number of Residues48
DetailsTRANSMEM: Helical; Name=2 => ECO:0000250
ChainResidueDetails
AILE86-LEU110
BILE86-LEU110

site_idSWS_FT_FI4
Number of Residues88
DetailsTOPO_DOM: Extracellular => ECO:0000250
ChainResidueDetails
AMET111-LYS122
AALA187-SER206
ATHR285-ALA299
BMET111-LYS122
BALA187-SER206
BTHR285-ALA299

site_idSWS_FT_FI5
Number of Residues42
DetailsTRANSMEM: Helical; Name=3 => ECO:0000250
ChainResidueDetails
AALA123-VAL144
BALA123-VAL144

site_idSWS_FT_FI6
Number of Residues44
DetailsTRANSMEM: Helical; Name=4 => ECO:0000250
ChainResidueDetails
ALYS164-MET186
BLYS164-MET186

site_idSWS_FT_FI7
Number of Residues62
DetailsTRANSMEM: Helical; Name=5 => ECO:0000250
ChainResidueDetails
ATRP207-LEU238
BTRP207-LEU238

site_idSWS_FT_FI8
Number of Residues44
DetailsTRANSMEM: Helical; Name=6 => ECO:0000250
ChainResidueDetails
AMET262-TRP284
BMET262-TRP284

site_idSWS_FT_FI9
Number of Residues42
DetailsTRANSMEM: Helical; Name=7 => ECO:0000250
ChainResidueDetails
ALEU300-LEU321
BLEU300-LEU321

site_idSWS_FT_FI10
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000255
ChainResidueDetails
ACYS333
BCYS333

218853

PDB entries from 2024-04-24

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