6GPS

CRYSTAL STRUCTURE OF CCR2A IN COMPLEX WITH MK-0812

Summary for 6GPS

• Entry DOI: 10.2210/pdb6gps/pdb
• Related: 5t1a
• Descriptor: C-C chemokine receptor type 2,Rubredoxin,C-C chemokine receptor type 2, ZINC ION, [(3~{S},4~{S})-3-methoxyoxan-4-yl]-[(1~{R},3~{S})-3-propan-2-yl-3-[[3-(trifluoromethyl)-7,8-dihydro-5~{H}-1,6-naphthyridin-6-yl]carbonyl]cyclopentyl]azanium (3 entities in total)
• Functional Keywords: gpcr, signalling, drug-design, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 48814.14

Authors

Pautsch, A.,Schnapp, G. (deposition date: 2018-06-07, release date: 2019-01-02, Last modification date: 2019-03-13)

• Primary citation: Apel, A.K.,Cheng, R.K.Y.,Tautermann, C.S.,Brauchle, M.,Huang, C.Y.,Pautsch, A.,Hennig, M.,Nar, H.,Schnapp, G.; Crystal Structure of CC Chemokine Receptor 2A in Complex with an Orthosteric Antagonist Provides Insights for the Design of Selective Antagonists.; Structure, 27:427-438.e5, 2019; PubMed: 30581043; DOI: 10.1016/j.str.2018.10.027

Experimental method

X-RAY DIFFRACTION (3.3 Å)