5T1A

Structure of CC Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists

Summary for 5T1A

• Entry DOI: 10.2210/pdb5t1a/pdb
• Descriptor: Chimera protein of CC chemokine receptor type 2 isoform B and T4-lysozyme,Lysozyme, (3S)-1-{(1S,2R,4R)-4-[methyl(propan-2-yl)amino]-2-propylcyclohexyl}-3-{[6-(trifluoromethyl)quinazolin-4-yl]amino}pyrrolidin-2-one, (2~{R})-1-(4-chloranyl-2-fluoranyl-phenyl)-2-cyclohexyl-3-ethanoyl-4-oxidanyl-2~{H}-pyrrol-5-one, ... (7 entities in total)
• Functional Keywords: c-c chemokine receptor type 2, dual antagonist, intracellular allosteric antagonist, cooperative binding, lipidic cubic phase, membrane protein, gpcr, structural genomics, psi-2, protein structure initiative, gpcr network, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 59577.95

Authors

Zheng, Y.,Qin, L.,Ortiz Zacarias, N.V.,de Vries, H.,Han, G.W.,Gustavsson, M.,Dabros, M.,Zhao, C.,Cherney, R.J.,Carter, P.,Stamos, D.,Abagyan, R.,Cherezov, V.,Stevens, R.C.,IJzerman, A.P.,Heitman, L.H.,Tebben, A.,Kufareva, I.,Handel, T.M. (deposition date: 2016-08-18, release date: 2016-12-14, Last modification date: 2023-10-04)

• Primary citation: Zheng, Y.,Qin, L.,Zacarias, N.V.,de Vries, H.,Han, G.W.,Gustavsson, M.,Dabros, M.,Zhao, C.,Cherney, R.J.,Carter, P.,Stamos, D.,Abagyan, R.,Cherezov, V.,Stevens, R.C.,IJzerman, A.P.,Heitman, L.H.,Tebben, A.,Kufareva, I.,Handel, T.M.; Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists.; Nature, 540:458-461, 2016; PubMed: 27926736; DOI: 10.1038/nature20605

Experimental method

X-RAY DIFFRACTION (2.806 Å)