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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5T1A

Structure of CC Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0004930	molecular_function	G protein-coupled receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0009253	biological_process	peptidoglycan catabolic process
A	0016020	cellular_component	membrane
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016998	biological_process	cell wall macromolecule catabolic process
A	0030430	cellular_component	host cell cytoplasm
A	0031640	biological_process	killing of cells of another organism
A	0042742	biological_process	defense response to bacterium
A	0044659	biological_process	viral release from host cell by cytolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue 73R A 1201

Chain	Residue
A	VAL37
A	GLN288
A	VAL289
A	GLU291
A	THR292
A	MET295
A	GLY41
A	LEU44
A	LEU45
A	TYR49
A	TRP98
A	THR117
A	TYR120
A	CYS190

site_id	AC2
Number of Residues	10
Details	binding site for residue VT5 A 1202

Chain	Residue
A	VAL63
A	THR77
A	ARG237
A	ALA241
A	VAL244
A	TYR305
A	GLY309
A	GLU310
A	LYS311
A	PHE312

site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 A 1203

Chain	Residue
A	LYS71
A	LYS311
A	ARG314
A	TYR315
A	LYS1135

site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 A 1204

Chain	Residue
A	SER236
A	ARG237
A	ARG1008
A	ARG1119
A	ARG1125

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 A 1205

Chain	Residue
A	PHE1114
A	THR1115
A	ASN1116
A	SER1117
A	ASN1132

site_id	AC6
Number of Residues	4
Details	binding site for residue SO4 A 1206

Chain	Residue
A	THR1142
A	PRO1143
A	ASN1144
A	ARG1145

site_id	AC7
Number of Residues	10
Details	binding site for residue OLC A 1207

Chain	Residue
A	PHE170
A	LYS180
A	TRP198
A	MET205
A	TYR222
A	ARG232
A	LYS239
A	ARG243
A	PHE246
A	THR247

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN A 1208

Chain	Residue
A	HIS144
A	GLU238
A	GLU1005
A	HOH1307

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. GGIfFIILLTIDRYLaI

Chain	Residue	Details
A	GLY126-ILE142

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	27
Details	TRANSMEM: Helical; Name=1 => ECO:0000255

Chain	Residue	Details
A	GLN43-CYS70

site_id	SWS_FT_FI2
Number of Residues	25
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	LYS71-TYR80
A	ASP137-THR153

site_id	SWS_FT_FI3
Number of Residues	19
Details	TRANSMEM: Helical; Name=2 => ECO:0000255

Chain	Residue	Details
A	LEU81-HIS100

site_id	SWS_FT_FI4
Number of Residues	56
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	SER101-LYS114
A	THR179-ARG206
A	GLN269-GLN285

site_id	SWS_FT_FI5
Number of Residues	21
Details	TRANSMEM: Helical; Name=3 => ECO:0000255

Chain	Residue	Details
A	LEU115-ILE136

site_id	SWS_FT_FI6
Number of Residues	24
Details	TRANSMEM: Helical; Name=4 => ECO:0000255

Chain	Residue	Details
A	VAL154-PHE178

site_id	SWS_FT_FI7
Number of Residues	19
Details	TRANSMEM: Helical; Name=5 => ECO:0000255

Chain	Residue	Details
A	ASN207-SER226

site_id	SWS_FT_FI8
Number of Residues	24
Details	TRANSMEM: Helical; Name=6 => ECO:0000255

Chain	Residue	Details
A	VAL244-PHE268

site_id	SWS_FT_FI9
Number of Residues	23
Details	TRANSMEM: Helical; Name=7 => ECO:0000255

Chain	Residue	Details
A	ALA286-GLY309

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Sulfotyrosine => ECO:0000269\|PubMed:11046064

Chain	Residue	Details
A	TYR26

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by JAK2 => ECO:0000269\|PubMed:9670957

Chain	Residue	Details
A	TYR139

site_id	SWS_FT_FI12
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN14

site_id	SWS_FT_FI13
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255\|HAMAP-Rule:MF_04110, ECO:0000269\|PubMed:3382407, ECO:0000269\|PubMed:7831309, ECO:0000269\|PubMed:8266098

Chain	Residue	Details
A	GLU1011

site_id	SWS_FT_FI14
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255\|HAMAP-Rule:MF_04110, ECO:0000269\|PubMed:1892846, ECO:0000269\|PubMed:3382407, ECO:0000269\|PubMed:7831309, ECO:0000269\|PubMed:8266098

Chain	Residue	Details
A	ASP1020

site_id	SWS_FT_FI15
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:8266098

Chain	Residue	Details
A	LEU1032
A	PHE1104

site_id	SWS_FT_FI16
Number of Residues	2
Details	BINDING: BINDING => ECO:0000303\|PubMed:7831309

Chain	Residue	Details
A	SER1117
A	ASN1132

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 921

Chain	Residue	Details
A	GLU1011	proton shuttle (general acid/base)
A	ASP1020	covalent catalysis

219140

PDB entries from 2024-05-01

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