PDB: 941 件ウェブページステータス検索Chemie searchBIRD

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6N9G	Crystal Structure of RGS7-Gbeta5 dimer 分子名称: Guanine nucleotide-binding protein subunit beta-5, Regulator of G-protein signaling 7 著者 Patil, D.N, Rangarajan, E, Izard, T, Martemyanov, K.A. 登録日 2018-12-03 公開日 2019-01-09 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.129 Å) 主引用文献 Structural organization of a major neuronal G protein regulator, the RGS7-G beta 5-R7BP complex. Elife, 7, 2018
6N4B	Cannabinoid Receptor 1-G Protein Complex 分子名称: CHOLESTEROL, Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Krishna Kumar, K, Shalev-Benami, M, Hu, H, Weis, W.I, Kobilka, B.K, Skiniotis, G. 登録日 2018-11-18 公開日 2019-01-30 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex. Cell, 176, 2019
6M8S	Crystal structure of the KCTD12 H1 domain in complex with Gbeta1gamma2 subunits 分子名称: BTB/POZ domain-containing protein KCTD12, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 著者 Zheng, S, Kruse, A.C. 登録日 2018-08-22 公開日 2019-02-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.71 Å) 主引用文献 Structural basis for KCTD-mediated rapid desensitization of GABABsignalling. Nature, 567, 2019
6M1I	CryoEM structure of human PAC1 receptor in complex with PACAP38 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Song, X, Wang, J, Zhang, D, Wang, H.W, Ma, Y. 登録日 2020-02-26 公開日 2020-03-11 最終更新日 2020-05-27 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism. Cell Res., 30, 2020
6M1H	CryoEM structure of human PAC1 receptor in complex with maxadilan 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Song, X, Wang, J, Zhang, D, Wang, H.W, Ma, Y. 登録日 2020-02-26 公開日 2020-03-11 最終更新日 2020-05-27 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism. Cell Res., 30, 2020
6LPB	Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Kobayashi, K, Shihoya, W, Nishizawa, T, Nureki, O. 登録日 2020-01-09 公開日 2020-03-11 最終更新日 2020-03-25 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein. Nat.Struct.Mol.Biol., 27, 2020
6LML	Cryo-EM structure of the human glucagon receptor in complex with Gi1 分子名称: Glucagon, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Qiao, A, Han, S, Li, X, Sun, F, Zhao, Q, Wu, B. 登録日 2019-12-26 公開日 2020-04-01 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structural basis of Gsand Girecognition by the human glucagon receptor. Science, 367, 2020
6LMK	Cryo-EM structure of the human glucagon receptor in complex with Gs 分子名称: Glucagon, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Qiao, A, Han, S, Tai, L, Sun, F, Zhao, Q, Wu, B. 登録日 2019-12-26 公開日 2020-04-01 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structural basis of Gsand Girecognition by the human glucagon receptor. Science, 367, 2020
6LI3	cryo-EM structure of GPR52-miniGs-NB35 分子名称: G-protein coupled receptor 52, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Li, M, Wang, N, Xu, F, Wu, J, Lei, M. 登録日 2019-12-10 公開日 2020-02-26 最終更新日 2020-03-18 実験手法 ELECTRON MICROSCOPY (3.32 Å) 主引用文献 Structural basis of ligand recognition and self-activation of orphan GPR52. Nature, 579, 2020
6LFO	Cryo-EM structure of a class A GPCR monomer 分子名称: C-X-C chemokine receptor type 2, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Liu, Z.J, Hua, T, Liu, K.W, Wu, L.J. 登録日 2019-12-03 公開日 2020-09-02 最終更新日 2020-09-16 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structural basis of CXC chemokine receptor 2 activation and signalling. Nature, 585, 2020
6LFM	Cryo-EM structure of a class A GPCR 分子名称: C-X-C chemokine receptor type 2, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Liu, Z.J, Hua, T, Liu, K.W, Wu, L.J. 登録日 2019-12-03 公開日 2020-09-02 最終更新日 2020-09-16 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural basis of CXC chemokine receptor 2 activation and signalling. Nature, 585, 2020
6KPG	Cryo-EM structure of CB1-G protein complex 分子名称: (6~{a}~{R},9~{R},10~{a}~{R})-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyl-octan-2-yl)-6,6-dimethyl-6~{a},7,8,9,10,10~{a}-hexahydrobenzo[c]chromen-1-ol, Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Hua, T, Li, X.T, Wu, L.J, Makriyannis, A, Wang, Y.X, Shen, L, Liu, Z.J. 登録日 2019-08-15 公開日 2020-02-12 最終更新日 2020-03-11 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-GiComplex Structures. Cell, 180, 2020
6KPF	Cryo-EM structure of a class A GPCR with G protein complex 分子名称: 7-[(6aR,9R,10aR)-1-Hydroxy-9-(hydroxymethyl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydro-6H-benzo[c]chromen-3-yl]- 7-methyloctanenitrile, Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Li, X.T, Hua, T, Wu, L.J, Makriyannis, A, Shen, L, Wang, Y.X, Liu, Z.J. 登録日 2019-08-15 公開日 2020-02-12 最終更新日 2022-04-27 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-GiComplex Structures. Cell, 180, 2020
6K42	cryo-EM structure of alpha2BAR-Gi1 complex 分子名称: 4-[(1~{S})-1-(2,3-dimethylphenyl)ethyl]-1~{H}-imidazole, Alpha-2A adrenergic receptor,Endolysin,Alpha-2B adrenergic receptor,Alpha-2B adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Yuan, D, Liu, Z, Wang, H.W, Kobilka, B.K. 登録日 2019-05-23 公開日 2020-04-15 最終更新日 2020-05-13 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Activation of the alpha2Badrenoceptor by the sedative sympatholytic dexmedetomidine. Nat.Chem.Biol., 16, 2020
6K41	cryo-EM structure of alpha2BAR-GoA complex 分子名称: 4-[(1~{S})-1-(2,3-dimethylphenyl)ethyl]-1~{H}-imidazole, Alpha-2A adrenergic receptor,Endolysin,Alpha-2B adrenergic receptor,Alpha-2B adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Yuan, D, Liu, Z, Wang, H.W, Kobilka, B.K. 登録日 2019-05-23 公開日 2020-04-15 最終更新日 2020-05-13 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Activation of the alpha2Badrenoceptor by the sedative sympatholytic dexmedetomidine. Nat.Chem.Biol., 16, 2020
6GDG	Cryo-EM structure of the adenosine A2A receptor bound to a miniGs heterotrimer 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Garcia-Nafria, J, Lee, Y. 登録日 2018-04-23 公開日 2018-05-16 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (4.11 Å) 主引用文献 Cryo-EM structure of the adenosine A2Areceptor coupled to an engineered heterotrimeric G protein. Elife, 7, 2018
6G79	Coupling specificity of heterotrimeric Go to the serotonin 5-HT1B receptor 分子名称: 2-[5-[2-[4-(4-cyanophenyl)piperazin-1-yl]-2-oxidanylidene-ethoxy]-1~{H}-indol-3-yl]ethylazanium, 5-hydroxytryptamine receptor 1B, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Garcia-Nafria, J, Nehme, R, Edwards, P, Tate, C.G. 登録日 2018-04-05 公開日 2018-06-20 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (3.78 Å) 主引用文献 Cryo-EM structure of the serotonin 5-HT1Breceptor coupled to heterotrimeric Go. Nature, 558, 2018
6EG8	Structure of the GDP-bound Gs heterotrimer 分子名称: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Hilger, D, Liu, X, Aschauer, P, Kobilka, B.K. 登録日 2018-08-19 公開日 2019-06-05 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural Insights into the Process of GPCR-G Protein Complex Formation. Cell, 177, 2019
6E3Y	Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor 分子名称: Calcitonin gene-related peptide 1, Calcitonin gene-related peptide type 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Liang, Y.L, Khoshouei, M, Deganutti, G, Glukhova, A, Koole, C, Peat, T.S, Radjainia, M, Plitzko, J.M, Baumeister, W, Miller, L.J, Hay, D.L, Christopoulos, A, Reynolds, C.A, Wootten, D, Sexton, P.M. 登録日 2018-07-16 公開日 2018-09-19 最終更新日 2020-01-15 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor. Nature, 561, 2018
6DDF	Mu Opioid Receptor-Gi Protein Complex 分子名称: DAMGO, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Koehl, A, Hu, H, Maeda, S, Manglik, A, Kobilka, B.K, Skiniotis, G, Weis, W.I. 登録日 2018-05-10 公開日 2018-06-13 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structure of the mu-opioid receptor-Giprotein complex. Nature, 558, 2018
6DDE	Mu Opioid Receptor-Gi Protein Complex 分子名称: DAMGO, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Koehl, A, Hu, H, Maeda, S, Manglik, A, Zhang, Y, Kobilka, B.K, Skiniotis, G, Weis, W.I. 登録日 2018-05-10 公開日 2018-06-13 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structure of the mu-opioid receptor-Giprotein complex. Nature, 558, 2018
6D9H	Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist 分子名称: ADENOSINE, Chimera protein of Muscarinic acetylcholine receptor M4 and Adenosine receptor A1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Draper-Joyce, C.J, Khoshouei, M, Thal, D.M, Liang, Y.-L, Nguyen, A.T.N, Furness, S.G.B, Venugopal, H, Baltos, J, Plitzko, J.M, Danev, R, Baumeister, W, May, L.T, Wootten, D, Sexton, P, Glukhova, A, Christopoulos, A. 登録日 2018-04-29 公開日 2018-06-20 最終更新日 2018-07-11 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structure of the adenosine-bound human adenosine A1receptor-Gicomplex. Nature, 558, 2018
6CRK	Heterotrimeric G-protein in complex with an antibody fragment 分子名称: CITRATE ANION, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Maeda, S, Dawson, R, Kobilka, B. 登録日 2018-03-19 公開日 2018-10-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Development of an antibody fragment that stabilizes GPCR/G-protein complexes. Nat Commun, 9, 2018
6CMO	Rhodopsin-Gi complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab Heavy chain, Fab light chain, ... 著者 Kang, Y, Kuybeda, O, de Waal, P.W, Mukherjee, S, Van Eps, N, Dutka, P, Zhou, X.E, Bartesaghi, A, Erramilli, S, Morizumi, T, Gu, X, Yin, Y, Liu, P, Jiang, Y, Meng, X, Zhao, G, Melcher, K, Earnst, O.P, Kossiakoff, A.A, Subramaniam, S, Xu, H.E. 登録日 2018-03-05 公開日 2018-06-20 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 Cryo-EM structure of human rhodopsin bound to an inhibitory G protein. Nature, 558, 2018
6C2Y	Human GRK2 in complex with Gbetagamma subunits and CCG257142 分子名称: (4R,5R,6S)-4-[4-fluoro-3-({[3-(methoxymethyl)-1,2,4-oxadiazol-5-yl]methyl}carbamoyl)phenyl]-N-(2H-indazol-5-yl)-6-methyl-2-oxohexahydropyrimidine-5-carboxamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Bouley, R, Tesmer, J.J.G. 登録日 2018-01-09 公開日 2018-04-25 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.74 Å) 主引用文献 Utilizing a structure-based docking approach to develop potent G protein-coupled receptor kinase (GRK) 2 and 5 inhibitors. Bioorg. Med. Chem. Lett., 28, 2018

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