6KPF

Cryo-EM structure of a class A GPCR with G protein complex

Summary for 6KPF

Entry DOI	10.2210/pdb6kpf/pdb
EMDB information	0744
Descriptor	Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
Functional Keywords	gpcr, gi protein, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	153600.28
Authors	Li, X.T.,Hua, T.,Wu, L.J.,Makriyannis, A.,Shen, L.,Wang, Y.X.,Liu, Z.J. (deposition date: 2019-08-15, release date: 2020-02-12, Last modification date: 2022-04-27)
Primary citation	Hua, T.,Li, X.,Wu, L.,Iliopoulos-Tsoutsouvas, C.,Wang, Y.,Wu, M.,Shen, L.,Johnston, C.A.,Nikas, S.P.,Song, F.,Song, X.,Yuan, S.,Sun, Q.,Wu, Y.,Jiang, S.,Grim, T.W.,Benchama, O.,Stahl, E.L.,Zvonok, N.,Zhao, S.,Bohn, L.M.,Makriyannis, A.,Liu, Z.J. Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-GiComplex Structures. Cell, 180:655-, 2020 Cited by PubMed: 32004463 DOI: 10.1016/j.cell.2020.01.008 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.9 Å)

Structure validation