6M8S

Crystal structure of the KCTD12 H1 domain in complex with Gbeta1gamma2 subunits

Summary for 6M8S

• Entry DOI: 10.2210/pdb6m8s/pdb
• Related: 6M8R
• Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, BTB/POZ domain-containing protein KCTD12 (3 entities in total)
• Functional Keywords: beta-propeller, homopentamer, gabab desensitization, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 15
• Total formula weight: 304886.23

Authors

Zheng, S.,Kruse, A.C. (deposition date: 2018-08-22, release date: 2019-02-27, Last modification date: 2023-10-11)

• Primary citation: Zheng, S.,Abreu, N.,Levitz, J.,Kruse, A.C.; Structural basis for KCTD-mediated rapid desensitization of GABABsignalling.; Nature, 567:127-131, 2019; PubMed: 30814734; DOI: 10.1038/s41586-019-0990-0

Experimental method

X-RAY DIFFRACTION (3.71 Å)