6M8S

Crystal structure of the KCTD12 H1 domain in complex with Gbeta1gamma2 subunits

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0001750	cellular_component	photoreceptor outer segment
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005765	cellular_component	lysosomal membrane
C	0005829	cellular_component	cytosol
C	0005834	cellular_component	heterotrimeric G-protein complex
C	0005886	cellular_component	plasma membrane
C	0007165	biological_process	signal transduction
C	0007186	biological_process	G protein-coupled receptor signaling pathway
C	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
C	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
C	0007213	biological_process	G protein-coupled acetylcholine receptor signaling pathway
C	0007265	biological_process	Ras protein signal transduction
C	0008283	biological_process	cell population proliferation
C	0016020	cellular_component	membrane
C	0030159	molecular_function	signaling receptor complex adaptor activity
C	0044877	molecular_function	protein-containing complex binding
C	0045202	cellular_component	synapse
C	0050909	biological_process	sensory perception of taste
C	0051020	molecular_function	GTPase binding
C	0060041	biological_process	retina development in camera-type eye
C	0070062	cellular_component	extracellular exosome
C	0071380	biological_process	cellular response to prostaglandin E stimulus
C	0071870	biological_process	cellular response to catecholamine stimulus
C	0097381	cellular_component	photoreceptor disc membrane
C	1903561	cellular_component	extracellular vesicle
D	0001750	cellular_component	photoreceptor outer segment
D	0003924	molecular_function	GTPase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005765	cellular_component	lysosomal membrane
D	0005829	cellular_component	cytosol
D	0005834	cellular_component	heterotrimeric G-protein complex
D	0005886	cellular_component	plasma membrane
D	0007165	biological_process	signal transduction
D	0007186	biological_process	G protein-coupled receptor signaling pathway
D	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
D	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
D	0007213	biological_process	G protein-coupled acetylcholine receptor signaling pathway
D	0007265	biological_process	Ras protein signal transduction
D	0008283	biological_process	cell population proliferation
D	0016020	cellular_component	membrane
D	0030159	molecular_function	signaling receptor complex adaptor activity
D	0044877	molecular_function	protein-containing complex binding
D	0045202	cellular_component	synapse
D	0050909	biological_process	sensory perception of taste
D	0051020	molecular_function	GTPase binding
D	0060041	biological_process	retina development in camera-type eye
D	0070062	cellular_component	extracellular exosome
D	0071380	biological_process	cellular response to prostaglandin E stimulus
D	0071870	biological_process	cellular response to catecholamine stimulus
D	0097381	cellular_component	photoreceptor disc membrane
D	1903561	cellular_component	extracellular vesicle
E	0005515	molecular_function	protein binding
E	0005834	cellular_component	heterotrimeric G-protein complex
E	0005886	cellular_component	plasma membrane
E	0007165	biological_process	signal transduction
E	0007186	biological_process	G protein-coupled receptor signaling pathway
E	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
E	0016020	cellular_component	membrane
E	0031681	molecular_function	G-protein beta-subunit binding
E	0045202	cellular_component	synapse
E	0048144	biological_process	fibroblast proliferation
E	0070062	cellular_component	extracellular exosome
E	0071380	biological_process	cellular response to prostaglandin E stimulus
E	0071870	biological_process	cellular response to catecholamine stimulus
F	0005515	molecular_function	protein binding
F	0005834	cellular_component	heterotrimeric G-protein complex
F	0005886	cellular_component	plasma membrane
F	0007165	biological_process	signal transduction
F	0007186	biological_process	G protein-coupled receptor signaling pathway
F	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
F	0016020	cellular_component	membrane
F	0031681	molecular_function	G-protein beta-subunit binding
F	0045202	cellular_component	synapse
F	0048144	biological_process	fibroblast proliferation
F	0070062	cellular_component	extracellular exosome
F	0071380	biological_process	cellular response to prostaglandin E stimulus
F	0071870	biological_process	cellular response to catecholamine stimulus
G	0001750	cellular_component	photoreceptor outer segment
G	0003924	molecular_function	GTPase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005765	cellular_component	lysosomal membrane
G	0005829	cellular_component	cytosol
G	0005834	cellular_component	heterotrimeric G-protein complex
G	0005886	cellular_component	plasma membrane
G	0007165	biological_process	signal transduction
G	0007186	biological_process	G protein-coupled receptor signaling pathway
G	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
G	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
G	0007213	biological_process	G protein-coupled acetylcholine receptor signaling pathway
G	0007265	biological_process	Ras protein signal transduction
G	0008283	biological_process	cell population proliferation
G	0016020	cellular_component	membrane
G	0030159	molecular_function	signaling receptor complex adaptor activity
G	0044877	molecular_function	protein-containing complex binding
G	0045202	cellular_component	synapse
G	0050909	biological_process	sensory perception of taste
G	0051020	molecular_function	GTPase binding
G	0060041	biological_process	retina development in camera-type eye
G	0070062	cellular_component	extracellular exosome
G	0071380	biological_process	cellular response to prostaglandin E stimulus
G	0071870	biological_process	cellular response to catecholamine stimulus
G	0097381	cellular_component	photoreceptor disc membrane
G	1903561	cellular_component	extracellular vesicle
H	0001750	cellular_component	photoreceptor outer segment
H	0003924	molecular_function	GTPase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005765	cellular_component	lysosomal membrane
H	0005829	cellular_component	cytosol
H	0005834	cellular_component	heterotrimeric G-protein complex
H	0005886	cellular_component	plasma membrane
H	0007165	biological_process	signal transduction
H	0007186	biological_process	G protein-coupled receptor signaling pathway
H	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
H	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
H	0007213	biological_process	G protein-coupled acetylcholine receptor signaling pathway
H	0007265	biological_process	Ras protein signal transduction
H	0008283	biological_process	cell population proliferation
H	0016020	cellular_component	membrane
H	0030159	molecular_function	signaling receptor complex adaptor activity
H	0044877	molecular_function	protein-containing complex binding
H	0045202	cellular_component	synapse
H	0050909	biological_process	sensory perception of taste
H	0051020	molecular_function	GTPase binding
H	0060041	biological_process	retina development in camera-type eye
H	0070062	cellular_component	extracellular exosome
H	0071380	biological_process	cellular response to prostaglandin E stimulus
H	0071870	biological_process	cellular response to catecholamine stimulus
H	0097381	cellular_component	photoreceptor disc membrane
H	1903561	cellular_component	extracellular vesicle
I	0005515	molecular_function	protein binding
I	0005834	cellular_component	heterotrimeric G-protein complex
I	0005886	cellular_component	plasma membrane
I	0007165	biological_process	signal transduction
I	0007186	biological_process	G protein-coupled receptor signaling pathway
I	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
I	0016020	cellular_component	membrane
I	0031681	molecular_function	G-protein beta-subunit binding
I	0045202	cellular_component	synapse
I	0048144	biological_process	fibroblast proliferation
I	0070062	cellular_component	extracellular exosome
I	0071380	biological_process	cellular response to prostaglandin E stimulus
I	0071870	biological_process	cellular response to catecholamine stimulus
J	0005515	molecular_function	protein binding
J	0005834	cellular_component	heterotrimeric G-protein complex
J	0005886	cellular_component	plasma membrane
J	0007165	biological_process	signal transduction
J	0007186	biological_process	G protein-coupled receptor signaling pathway
J	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
J	0016020	cellular_component	membrane
J	0031681	molecular_function	G-protein beta-subunit binding
J	0045202	cellular_component	synapse
J	0048144	biological_process	fibroblast proliferation
J	0070062	cellular_component	extracellular exosome
J	0071380	biological_process	cellular response to prostaglandin E stimulus
J	0071870	biological_process	cellular response to catecholamine stimulus
K	0001750	cellular_component	photoreceptor outer segment
K	0003924	molecular_function	GTPase activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005765	cellular_component	lysosomal membrane
K	0005829	cellular_component	cytosol
K	0005834	cellular_component	heterotrimeric G-protein complex
K	0005886	cellular_component	plasma membrane
K	0007165	biological_process	signal transduction
K	0007186	biological_process	G protein-coupled receptor signaling pathway
K	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
K	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
K	0007213	biological_process	G protein-coupled acetylcholine receptor signaling pathway
K	0007265	biological_process	Ras protein signal transduction
K	0008283	biological_process	cell population proliferation
K	0016020	cellular_component	membrane
K	0030159	molecular_function	signaling receptor complex adaptor activity
K	0044877	molecular_function	protein-containing complex binding
K	0045202	cellular_component	synapse
K	0050909	biological_process	sensory perception of taste
K	0051020	molecular_function	GTPase binding
K	0060041	biological_process	retina development in camera-type eye
K	0070062	cellular_component	extracellular exosome
K	0071380	biological_process	cellular response to prostaglandin E stimulus
K	0071870	biological_process	cellular response to catecholamine stimulus
K	0097381	cellular_component	photoreceptor disc membrane
K	1903561	cellular_component	extracellular vesicle
L	0005515	molecular_function	protein binding
L	0005834	cellular_component	heterotrimeric G-protein complex
L	0005886	cellular_component	plasma membrane
L	0007165	biological_process	signal transduction
L	0007186	biological_process	G protein-coupled receptor signaling pathway
L	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
L	0016020	cellular_component	membrane
L	0031681	molecular_function	G-protein beta-subunit binding
L	0045202	cellular_component	synapse
L	0048144	biological_process	fibroblast proliferation
L	0070062	cellular_component	extracellular exosome
L	0071380	biological_process	cellular response to prostaglandin E stimulus
L	0071870	biological_process	cellular response to catecholamine stimulus

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS

Chain	Residue	Details
C	LEU70-SER84
C	ILE157-ILE171
C	LEU285-ALA299

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	240
Details	Repeat: {"description":"WD 1","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	200
Details	Repeat: {"description":"WD 3","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	205
Details	Repeat: {"description":"WD 4","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	215
Details	Repeat: {"description":"WD 5","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	205
Details	Repeat: {"description":"WD 6","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	150
Details	Repeat: {"description":"WD 7","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	5
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	5
Details	Modified residue: {"description":"Phosphohistidine","evidences":[{"source":"UniProtKB","id":"P62871","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---