6M8S

Crystal structure of the KCTD12 H1 domain in complex with Gbeta1gamma2 subunits

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, G (C, D, G, H, K)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	350	38534.1	5	UniProt (P62873) Pfam (PF00400)	Homo sapiens (Human)	Transducin beta chain 1
2	E, F, H, M, N (I, J, L, E, F)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7845.1	5	UniProt (P59768) Pfam (PF00631)	Homo sapiens (Human)	G gamma-I
3	I, J, K, L, O (A, O, P, B, M)	BTB/POZ domain-containing protein KCTD12	polymer	129	14598.1	5	UniProt (Q96CX2)	Homo sapiens (Human)	Pfetin,Predominantly fetal expressed T1 domain

Sequence modifications

C, D, G, H, K: 2 - 340 (UniProt: P62873)

PDB	External Database	Details
Met -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Ser 0	-	expression tag
Gly 1	-	expression tag

I, J, L, E, F: 1 - 71 (UniProt: P59768)

PDB	External Database	Details
Ser 68	Cys 68	conflict

A, O, P, B, M: 200 - 325 (UniProt: Q96CX2)

PDB	External Database	Details
Gly 197	-	expression tag
Pro 198	-	expression tag
Glu 199	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	15
	Total formula weight	304886.2
All*	Total formula weight	304886.2

*Water molecules are not included.