6D9H
Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist
Summary for 6D9H
Entry DOI | 10.2210/pdb6d9h/pdb |
EMDB information | 7835 |
Descriptor | Guanine nucleotide-binding protein G(i) subunit alpha-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (5 entities in total) |
Functional Keywords | signaling protein, membrane protein, active-state g protein-coupled receptor, adenosine a1 receptor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 130702.62 |
Authors | Draper-Joyce, C.J.,Khoshouei, M.,Thal, D.M.,Liang, Y.-L.,Nguyen, A.T.N.,Furness, S.G.B.,Venugopal, H.,Baltos, J.,Plitzko, J.M.,Danev, R.,Baumeister, W.,May, L.T.,Wootten, D.,Sexton, P.,Glukhova, A.,Christopoulos, A. (deposition date: 2018-04-29, release date: 2018-06-20, Last modification date: 2018-07-11) |
Primary citation | Draper-Joyce, C.J.,Khoshouei, M.,Thal, D.M.,Liang, Y.L.,Nguyen, A.T.N.,Furness, S.G.B.,Venugopal, H.,Baltos, J.A.,Plitzko, J.M.,Danev, R.,Baumeister, W.,May, L.T.,Wootten, D.,Sexton, P.M.,Glukhova, A.,Christopoulos, A. Structure of the adenosine-bound human adenosine A1receptor-Gicomplex. Nature, 558:559-563, 2018 Cited by PubMed: 29925945DOI: 10.1038/s41586-018-0236-6 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.6 Å) |
Structure validation
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