PDB: 325 件ウェブページステータス検索Chemie searchBIRD

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7U22	Mycobacterium tuberculosis RNA polymerase sigma A holoenzyme open promoter complex containing UMN-7 分子名称: (9S,14S,15R,16S,17R,18R,19R,20S,21S,25R)-5,6,18,20-tetrahydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1'-(2-methylpropyl)-10,26-dioxo-1,3,9,10-tetrahydrospiro[9,4-(epoxypentadecanoimino)furo[2',3':7,8]naphtho[1,2-d]imidazole-2,4'-piperidin]-16-yl benzoate, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Molodtsov, V, Ebright, R.H. 登録日 2022-02-22 公開日 2022-10-19 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.87 Å) 主引用文献 Redesign of Rifamycin Antibiotics to Overcome ADP-Ribosylation-Mediated Resistance. Angew.Chem.Int.Ed.Engl., 61, 2022
7RDQ	Cryo-EM structure of Thermus thermophilus reiterative transcription complex with 11nt oligo-G RNA 分子名称: DNA (31-MER) nontemplate strand, DNA (31-MER) template strand, DNA-directed RNA polymerase subunit alpha, ... 著者 Liu, Y, Ebright, R.H. 登録日 2021-07-10 公開日 2022-02-02 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural and mechanistic basis of reiterative transcription initiation. Proc.Natl.Acad.Sci.USA, 119, 2022
5E18	T. thermophilus transcription initiation complex having a YYY discriminator sequence and a nontemplate-strand length corresponding to TSS selection at position 8 (RPo-CCC-8) 分子名称: DNA (28-MER), DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Zhang, Y, Ebright, R.H. 登録日 2015-09-29 公開日 2016-03-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Multiplexed protein-DNA cross-linking: Scrunching in transcription start site selection. Science, 351, 2016
5D4E	Crystal structure of Thermus thermophilus product complex for transcription initiation with 3'-dephosphate-CoA and CTP 分子名称: CYTIDINE-5'-MONOPHOSPHATE, DEPHOSPHO COENZYME A, DIPHOSPHATE, ... 著者 Zhang, Y, Ebright, R.H. 登録日 2015-08-07 公開日 2016-07-06 最終更新日 2024-07-03 実験手法 X-RAY DIFFRACTION (3.08 Å) 主引用文献 The mechanism of RNA 5' capping with NAD(+), NADH and desphospho-CoA. Nature, 535, 2016
7SZK	Cryo-EM structure of 27a bound to E. coli RNAP and rrnBP1 promoter complex 分子名称: (2S,7R,7aR,13aP,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-5,21,23-trihydroxy-27-methoxy-2,4,16,20,22,24,26-heptamethyl-10-[4-(2-methylpropyl)piperazin-1-yl]-12-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1,6,15-trioxo-1,2,7,7a-tetrahydro-6H-2,7-(epoxypentadeca[1,11,13]trienoimino)[1]benzofuro[4,5-a]phenoxazin-25-yl acetate, DNA (5'-D(P*CP*TP*CP*GP*TP*AP*GP*AP*GP*TP*CP*CP*GP*TP*GP*TP*CP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Shin, Y, Murakami, K.S. 登録日 2021-11-28 公開日 2022-07-13 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (2.94 Å) 主引用文献 Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis. Acs Infect Dis., 8, 2022
5D4D	Crystal structure of Thermus thermophilus product complex for transcription initiation with NAD and CTP 分子名称: ADENOSINE MONOPHOSPHATE, CYTIDINE-5'-MONOPHOSPHATE, CYTIDINE-5'-TRIPHOSPHATE, ... 著者 Zhang, Y, Ebright, R.H. 登録日 2015-08-07 公開日 2016-07-06 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The mechanism of RNA 5' capping with NAD(+), NADH and desphospho-CoA. Nature, 535, 2016
7SZJ	Cryo-EM structure of Rifamycin bound to E. coli RNAP and rrnBP1 promoter complex 分子名称: DNA (49-MER), DNA (57-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Shin, Y, Murakami, K.S. 登録日 2021-11-28 公開日 2022-07-13 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (3.11 Å) 主引用文献 Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis. Acs Infect Dis., 8, 2022
7RWI	Mycobacterium tuberculosis RNA polymerase sigma L holoenzyme open promoter complex containing TNP-2198 分子名称: (3aM,9S,10bP,14S,15R,16S,17R,18R,19R,20S,21S,25R)-6,18,20-trihydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1'-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]-5,10,26-trioxo-3,5,9,10-tetrahydrospiro[9,4-(epoxypentadecanoimino)furo[2',3':7,8]naphtho[1,2-d]imidazole-2,4'-piperidin]-16-yl acetate, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Molodtsov, V, Ebright, R.H. 登録日 2021-08-19 公開日 2022-03-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. J.Med.Chem., 65, 2022
5E17	T. thermophilus transcription initiation complex having a RRR discriminator sequence and a nontemplate-strand length corresponding to TSS selection at position 7 (RPo-GGG-7) 分子名称: DNA (27-MER), DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Zhang, Y, Ebright, R.H. 登録日 2015-09-29 公開日 2016-03-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Multiplexed protein-DNA cross-linking: Scrunching in transcription start site selection. Science, 351, 2016
7KHE	Escherichia coli RNA polymerase and rrnBP1 promoter pre-open complex with DksA/ppGpp 分子名称: CHAPSO, DNA (46-MER), DNA (54-MER), ... 著者 Shin, Y, Qayyum, M.Z, Murakami, K.S. 登録日 2020-10-21 公開日 2020-12-09 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.58 Å) 主引用文献 Structural basis of ribosomal RNA transcription regulation. Nat Commun, 12, 2021
7KHB	Escherichia coli RNA polymerase and rrnBP1 promoter open complex 分子名称: CHAPSO, DNA (60-MER), DNA (64-MER), ... 著者 Shin, Y, Qayyum, M.Z, Murakami, K.S. 登録日 2020-10-20 公開日 2020-10-28 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.53 Å) 主引用文献 Structural basis of ribosomal RNA transcription regulation. Nat Commun, 12, 2021
7KHC	Escherichia coli RNA polymerase and rrnBP1 promoter closed complex 分子名称: CHAPSO, DNA (18 MER), DNA (63-MER), ... 著者 Shin, Y, Qayyum, M.Z, Murakami, K.S. 登録日 2020-10-20 公開日 2020-10-28 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (4.14 Å) 主引用文献 Structural basis of ribosomal RNA transcription regulation. Nat Commun, 12, 2021
1L0O	Crystal Structure of the Bacillus stearothermophilus Anti-Sigma Factor SpoIIAB with the Sporulation Sigma Factor SigmaF 分子名称: ADENOSINE-5'-DIPHOSPHATE, Anti-sigma F factor, MAGNESIUM ION, ... 著者 Campbell, E.A, Masuda, S, Sun, J.L, Muzzin, O, Olson, C.A, Wang, S, Darst, S.A. 登録日 2002-02-12 公開日 2002-04-03 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of the Bacillus stearothermophilus anti-sigma factor SpoIIAB with the sporulation sigma factor sigmaF. Cell(Cambridge,Mass.), 108, 2002
1L9U	THERMUS AQUATICUS RNA POLYMERASE HOLOENZYME AT 4 A RESOLUTION 分子名称: MAGNESIUM ION, RNA POLYMERASE, ALPHA SUBUNIT, ... 著者 Murakami, K.S, Masuda, S, Darst, S.A. 登録日 2002-03-26 公開日 2002-05-22 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 Structural basis of transcription initiation: RNA polymerase holoenzyme at 4 A resolution. Science, 296, 2002
6VVZ	Mycobacterium tuberculosis RNAP S456L mutant transcription initiation intermediate structure with Sorangicin 分子名称: DNA (62-MER), DNA (65-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Lilic, M, Boyaci, H, Chen, J, Darst, S.A, Campbell, E.A. 登録日 2020-02-18 公開日 2020-10-21 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.72 Å) 主引用文献 The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc.Natl.Acad.Sci.USA, 117, 2020
6VVT	Crystal structure of a Mycobacterium smegmatis transcription initiation complex with Rifampicin-resistant RNA polymerase and antibiotic Sorangicin 分子名称: 1,2-ETHANEDIOL, DNA (26-MER), DNA (31-MER), ... 著者 Lilic, M, Darst, S.A, Campbell, E.A. 登録日 2020-02-18 公開日 2020-10-21 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.901 Å) 主引用文献 The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc.Natl.Acad.Sci.USA, 117, 2020
6VJS	Escherichia coli RNA polymerase and ureidothiophene-2-carboxylic acid complex 分子名称: 3-{[benzyl(ethyl)carbamoyl]amino}-5-(4-phenoxyphenyl)thiophene-2-carboxylic acid, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Murakami, K.S, Molodtsov, V. 登録日 2020-01-17 公開日 2020-10-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (4.02 Å) 主引用文献 Evaluation of Bacterial RNA Polymerase Inhibitors in a Staphylococcus aureus -Based Wound Infection Model in SKH1 Mice. Acs Infect Dis., 6, 2020
6VVY	Mycobacterium tuberculosis WT RNAP transcription open promoter complex with Sorangicin 分子名称: DNA (65-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Lilic, M, Boyaci, H, Chen, J, Darst, S.A, Campbell, E.A. 登録日 2020-02-18 公開日 2020-10-21 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.42 Å) 主引用文献 The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc.Natl.Acad.Sci.USA, 117, 2020
6VVV	Crystal structure of a Mycobacterium smegmatis transcription initiation complex with Rifampicin-resistant RNA polymerase 分子名称: DNA (26-MER), DNA (31-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Lilic, M, Darst, S.A, Campbell, E.A. 登録日 2020-02-18 公開日 2020-10-21 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc.Natl.Acad.Sci.USA, 117, 2020
1SMY	Structural basis for transcription regulation by alarmone ppGpp 分子名称: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... 著者 Artsimovitch, I, Patlan, V, Sekine, S, Vassylyeva, M.N, Hosaka, T, Ochi, K, Yokoyama, S, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2004-03-10 公開日 2004-05-18 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural basis for transcription regulation by alarmone ppGpp Cell(Cambridge,Mass.), 117, 2004
8HVR	Cryo-EM structure of AfsR-dependent transcription activation complex with afsS promoter 分子名称: DNA (65-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Wang, Y, Zheng, J. 登録日 2022-12-27 公開日 2023-12-27 最終更新日 2024-04-03 実験手法 ELECTRON MICROSCOPY (3.35 Å) 主引用文献 Structural and functional characterization of AfsR, an SARP family transcriptional activator of antibiotic biosynthesis in Streptomyces. Plos Biol., 22, 2024
2CW0	Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution 分子名称: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... 著者 Tuske, S, Sarafianos, S.G, Wang, X, Hudson, B, Sineva, E, Mukhopadhyay, J, Birktoft, J.J, Leroy, O, Ismail, S, Clark Jr, A.D, Dharia, C, Napoli, A, Laptenko, O, Lee, J, Borukhov, S, Ebright, R.H, Arnold, E. 登録日 2005-06-15 公開日 2005-09-20 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation Cell(Cambridge,Mass.), 122, 2005
6VW0	Mycobacterium tuberculosis RNAP S456L mutant open promoter complex 分子名称: DNA (65-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Lilic, M, Boyaci, H, Chen, J, Darst, S.A, Campbell, E.A. 登録日 2020-02-18 公開日 2020-10-21 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.59 Å) 主引用文献 The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc.Natl.Acad.Sci.USA, 117, 2020
4G7H	Crystal structure of Thermus thermophilus transcription initiation complex 分子名称: 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', DNA-directed RNA polymerase subunit alpha, ... 著者 Zhang, Y, Ebright, R.H. 登録日 2012-07-20 公開日 2012-10-31 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis of transcription initiation. Science, 338, 2012
8JO2	Structural basis of transcriptional activation by the OmpR/PhoB-family response regulator PmrA 分子名称: DNA (65-MER), DNA-binding transcriptional regulator BasR, DNA-directed RNA polymerase subunit alpha, ... 著者 Lou, Y.-C, Huang, H.-Y, Chen, C, Wu, K.-P. 登録日 2023-06-06 公開日 2023-08-30 最終更新日 2023-10-25 実験手法 ELECTRON MICROSCOPY (2.74 Å) 主引用文献 Structural basis of transcriptional activation by the OmpR/PhoB-family response regulator PmrA. Nucleic Acids Res., 51, 2023

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