6VVY

Mycobacterium tuberculosis WT RNAP transcription open promoter complex with Sorangicin

Summary for 6VVY

Entry DOI	10.2210/pdb6vvy/pdb
EMDB information	21406 21407 21408 21409
Descriptor	DNA-directed RNA polymerase subunit alpha, SORANGICIN A, ZINC ION, ... (12 entities in total)
Functional Keywords	initiation, transcription bubble, antibiotic, sorangicin, open promoter complex, transcription, transferase-dna-antibiotic complex, transferase/dna/antibiotic
Biological source	Mycobacterium tuberculosis More
Total number of polymer chains	10
Total formula weight	511125.78
Authors	Lilic, M.,Boyaci, H.,Chen, J.,Darst, S.A.,Campbell, E.A. (deposition date: 2020-02-18, release date: 2020-10-21, Last modification date: 2024-03-06)
Primary citation	Lilic, M.,Chen, J.,Boyaci, H.,Braffman, N.,Hubin, E.A.,Herrmann, J.,Muller, R.,Mooney, R.,Landick, R.,Darst, S.A.,Campbell, E.A. The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc.Natl.Acad.Sci.USA, 117:30423-30432, 2020 Cited by PubMed: 33199626 DOI: 10.1073/pnas.2013706117 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.42 Å)

Structure validation