6VVV

Crystal structure of a Mycobacterium smegmatis transcription initiation complex with Rifampicin-resistant RNA polymerase

Summary for 6VVV

• Entry DOI: 10.2210/pdb6vvv/pdb
• Descriptor: RNA polymerase-binding protein RbpA, ZINC ION, DNA-directed RNA polymerase subunit alpha, ... (11 entities in total)
• Functional Keywords: dna binding, antibiotic, transcription, transferase-dna complex, transferase/dna
• Biological source: Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155); More
• Total number of polymer chains: 10
• Total formula weight: 484273.40

Authors

Lilic, M.,Darst, S.A.,Campbell, E.A. (deposition date: 2020-02-18, release date: 2020-10-21, Last modification date: 2023-10-11)

• Primary citation: Lilic, M.,Chen, J.,Boyaci, H.,Braffman, N.,Hubin, E.A.,Herrmann, J.,Muller, R.,Mooney, R.,Landick, R.,Darst, S.A.,Campbell, E.A.; The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase.; Proc.Natl.Acad.Sci.USA, 117:30423-30432, 2020; PubMed: 33199626; DOI: 10.1073/pnas.2013706117

Experimental method

X-RAY DIFFRACTION (3.2 Å)