6VVZ
Mycobacterium tuberculosis RNAP S456L mutant transcription initiation intermediate structure with Sorangicin
Summary for 6VVZ
Entry DOI | 10.2210/pdb6vvz/pdb |
EMDB information | 21406 21407 21408 21409 |
Descriptor | DNA-directed RNA polymerase subunit alpha, SORANGICIN A, ZINC ION, ... (12 entities in total) |
Functional Keywords | initiation, transcription bubble, antibiotic, sorangicin, open promoter complex, transcription, transferase-dna-antibiotic complex, transferase/dna/antibiotic |
Biological source | Mycobacterium tuberculosis More |
Total number of polymer chains | 10 |
Total formula weight | 511151.86 |
Authors | Lilic, M.,Boyaci, H.,Chen, J.,Darst, S.A.,Campbell, E.A. (deposition date: 2020-02-18, release date: 2020-10-21, Last modification date: 2024-03-06) |
Primary citation | Lilic, M.,Chen, J.,Boyaci, H.,Braffman, N.,Hubin, E.A.,Herrmann, J.,Muller, R.,Mooney, R.,Landick, R.,Darst, S.A.,Campbell, E.A. The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc.Natl.Acad.Sci.USA, 117:30423-30432, 2020 Cited by PubMed: 33199626DOI: 10.1073/pnas.2013706117 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.72 Å) |
Structure validation
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