7SZJ
Cryo-EM structure of Rifamycin bound to E. coli RNAP and rrnBP1 promoter complex
Summary for 7SZJ
Entry DOI | 10.2210/pdb7szj/pdb |
EMDB information | 25570 25571 |
Descriptor | DNA-directed RNA polymerase subunit alpha, ZINC ION, DNA-directed RNA polymerase subunit beta, ... (10 entities in total) |
Functional Keywords | transcription, antibiotics, rifamycin, transferase-dna-antibiotic complex, transferase/dna/antibiotic |
Biological source | Escherichia coli K-12 More |
Total number of polymer chains | 8 |
Total formula weight | 500341.14 |
Authors | Shin, Y.,Murakami, K.S. (deposition date: 2021-11-28, release date: 2022-07-13, Last modification date: 2024-02-28) |
Primary citation | Rajeswaran, W.,Ashkar, S.R.,Lee, P.H.,Yeomans, L.,Shin, Y.,Franzblau, S.G.,Murakami, K.S.,Showalter, H.D.,Garcia, G.A. Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis. Acs Infect Dis., 8:1422-1438, 2022 Cited by PubMed: 35772744DOI: 10.1021/acsinfecdis.1c00636 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.11 Å) |
Structure validation
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