7RWI

Mycobacterium tuberculosis RNA polymerase sigma L holoenzyme open promoter complex containing TNP-2198

Summary for 7RWI

Entry DOI	10.2210/pdb7rwi/pdb
Descriptor	DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... (8 entities in total)
Functional Keywords	mycobacterium tuberculosis, rna polymerase, transcription inhibitor, tnp-2198, open promoter complex, transcription-inhibitor complex, transcription/inhibitor
Biological source	Mycobacterium tuberculosis More
Total number of polymer chains	8
Total formula weight	400329.70
Authors	Molodtsov, V.,Ebright, R.H. (deposition date: 2021-08-19, release date: 2022-03-02, Last modification date: 2023-10-18)
Primary citation	Ma, Z.,He, S.,Yuan, Y.,Zhuang, Z.,Liu, Y.,Wang, H.,Chen, J.,Xu, X.,Ding, C.,Molodtsov, V.,Lin, W.,Robertson, G.T.,Weiss, W.J.,Pulse, M.,Nguyen, P.,Duncan, L.,Doyle, T.,Ebright, R.H.,Lynch, A.S. Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. J.Med.Chem., 65:4481-4495, 2022 Cited by PubMed: 35175750 DOI: 10.1021/acs.jmedchem.1c02045 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.7 Å)

Structure validation