2CW0

Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution

Summary for 2CW0

DescriptorDNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... (7 entities in total)
Functional Keywordsrna polymerase holoenzyme, transcription, bent-bridge helix, transferase
Biological sourceThermus thermophilus
Total number of polymer chains12
Total molecular weight853581.22
Authors
Primary citation
Tuske, S.,Sarafianos, S.G.,Wang, X.,Hudson, B.,Sineva, E.,Mukhopadhyay, J.,Birktoft, J.J.,Leroy, O.,Ismail, S.,Clark Jr., A.D.,Dharia, C.,Napoli, A.,Laptenko, O.,Lee, J.,Borukhov, S.,Ebright, R.H.,Arnold, E.
Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation
Cell(Cambridge,Mass.), 122:541-552, 2005
PubMed: 16122422 (PDB entries with the same primary citation)
DOI: 10.1016/j.cell.2005.07.017
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.3 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers6310.5%14.7%2.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2cw0
no rotation
Molmil generated image of 2cw0
rotated about x axis by 90°
Molmil generated image of 2cw0
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 2cw0
no rotation
Molmil generated image of 2cw0
rotated about x axis by 90°
Molmil generated image of 2cw0
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2cw0.pdb2.gz [550.98 KB])
Coordinate files for Biological unit (2cw0.pdb1.gz [548.88 KB])
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