Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution

Summary for 2CW0

DescriptorDNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... (7 entities in total)
Functional Keywordsrna polymerase holoenzyme, transcription, bent-bridge helix, transferase
Biological sourceThermus thermophilus
Total number of polymer chains12
Total molecular weight853581.22
Primary citation
Tuske, S.,Sarafianos, S.G.,Wang, X.,Hudson, B.,Sineva, E.,Mukhopadhyay, J.,Birktoft, J.J.,Leroy, O.,Ismail, S.,Clark Jr., A.D.,Dharia, C.,Napoli, A.,Laptenko, O.,Lee, J.,Borukhov, S.,Ebright, R.H.,Arnold, E.
Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation
Cell(Cambridge,Mass.), 122:541-552, 2005
PubMed: 16122422 (PDB entries with the same primary citation)
DOI: 10.1016/j.cell.2005.07.017
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers63 10.5% 14.7% 2.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report