2CW0

Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, K, L	DNA-directed RNA polymerase alpha chain	polymer	315	35056.2	4	UniProt (Q5SHR6) Pfam (PF01193) Pfam (PF01000) Pfam (PF03118) In PDB	Thermus thermophilus	DNA directed RNA polymerase holoenzyme subunit alpha, RNAP alpha subunit, Transcriptase alpha chain, RNA polymerase alpha subunit
2	C, M	DNA-directed RNA polymerase beta chain	polymer	1119	125436.5	2	UniProt (Q8RQE9) Pfam (PF04563) Pfam (PF04561) Pfam (PF04565) Pfam (PF10385) Pfam (PF00562) Pfam (PF04560) In PDB	Thermus thermophilus	DNA directed RNA polymerase holoenzyme subunit Beta, RNAP beta subunit, Transcriptase beta chain, RNA polymerase beta subunit
3	D, N	DNA-directed RNA polymerase beta' chain	polymer	1524	170997.4	2	UniProt (Q8RQE8) Pfam (PF04997) Pfam (PF21668) Pfam (PF00623) Pfam (PF04983) Pfam (PF05000) Pfam (PF04998) In PDB	Thermus thermophilus	DNA directed RNA polymerase holoenzyme subunit Beta-prime, RNAP beta' subunit, Transcriptase beta' chain, RNA polymerase beta' subunit
4	E, O	RNA polymerase omega chain	polymer	99	11521.2	2	UniProt (Q8RQE7) Pfam (PF01192) In PDB	Thermus thermophilus	DNA directed RNA polymerase holoenzyme subunit Omega
5	F, P	RNA polymerase sigma factor rpoD	polymer	423	48568.0	2	UniProt (Q5SKW1) Pfam (PF00140) Pfam (PF04542) Pfam (PF04539) Pfam (PF04545) In PDB	Thermus thermophilus	DNA directed RNA polymerase holoenzyme subunit Sigma
6	D, N	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
7	D, N	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	853271.0
Non-Polymers*	Number of molecules	6
	Total formula weight	310.2
All*	Total formula weight	853581.2

*Water molecules are not included.