7SR8
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![BU of 7sr8 by Molmil](/molmil-images/mine/7sr8) | Molecular mechanism of the the wake-promoting agent TAK-925 | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Hypocretin receptor type 2, ... | 著者 | Yin, J, Chapman, K, Lian, P, De Brabander, J.K, Rosenbaum, D.M. | 登録日 | 2021-11-08 | 公開日 | 2022-06-08 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Molecular mechanism of the wake-promoting agent TAK-925. Nat Commun, 13, 2022
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7SRS
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![BU of 7srs by Molmil](/molmil-images/mine/7srs) | 5-HT2B receptor bound to LSD in complex with beta-arrestin1 obtained by cryo-electron microscopy (cryoEM) | 分子名称: | (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 2B, ... | 著者 | Barros-Alvarez, X, Cao, C, Panova, O, Roth, B.L, Skiniotis, G. | 登録日 | 2021-11-08 | 公開日 | 2022-09-21 | 最終更新日 | 2022-10-19 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD. Neuron, 110, 2022
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7SUS
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![BU of 7sus by Molmil](/molmil-images/mine/7sus) | Crystal structure of Apelin receptor in complex with small molecule | 分子名称: | (1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Apelin receptor, ... | 著者 | Xu, F, Yue, Y, Liu, L.E, Han, G.W, Hanson, M. | 登録日 | 2021-11-18 | 公開日 | 2022-07-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural insight into apelin receptor-G protein stoichiometry. Nat.Struct.Mol.Biol., 29, 2022
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7T9I
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![BU of 7t9i by Molmil](/molmil-images/mine/7t9i) | Native human TSH bound to human Thyrotropin receptor in complex with miniGs399 (composite structure) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein hormones alpha chain, ... | 著者 | Faust, B, Cheng, Y, Manglik, A. | 登録日 | 2021-12-19 | 公開日 | 2022-08-03 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Autoantibody mimicry of hormone action at the thyrotropin receptor. Nature, 609, 2022
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7T9N
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![BU of 7t9n by Molmil](/molmil-images/mine/7t9n) | M22 Agonist Autoantibody bound to Human Thyrotropin receptor in complex with miniGs399 (composite structure) | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Faust, B, Cheng, Y, Manglik, A. | 登録日 | 2021-12-19 | 公開日 | 2022-08-03 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Autoantibody mimicry of hormone action at the thyrotropin receptor. Nature, 609, 2022
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7T32
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![BU of 7t32 by Molmil](/molmil-images/mine/7t32) | CryoEM structure of the adenosine 2A receptor-BRIL/Anti BRIL Fab complex with ZM241385 | 分子名称: | 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, Adenosine receptor A2a/Soluble cytochrome b562 Fusion Protein | 著者 | Zhang, K.H, Wu, H, Hoppe, N, Manglik, A, Cheng, Y.F. | 登録日 | 2021-12-06 | 公開日 | 2022-08-10 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Fusion protein strategies for cryo-EM study of G protein-coupled receptors. Nat Commun, 13, 2022
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7T9M
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![BU of 7t9m by Molmil](/molmil-images/mine/7t9m) | Human Thyrotropin receptor bound by CS-17 Inverse Agonist Fab/Org 274179-0 Antagonist | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CS-17 Heavy Chain, ... | 著者 | Faust, B, Cheng, Y, Manglik, A. | 登録日 | 2021-12-19 | 公開日 | 2022-08-10 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Autoantibody mimicry of hormone action at the thyrotropin receptor. Nature, 609, 2022
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7T2H
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![BU of 7t2h by Molmil](/molmil-images/mine/7t2h) | CryoEM structure of mu-opioid receptor - Gi protein complex bound to lofentanil (LFT) | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Seven, A.B, Qu, Q, Huang, W, Robertson, M.J, Kobilka, B.K, Skiniotis, G. | 登録日 | 2021-12-04 | 公開日 | 2022-12-07 | 最終更新日 | 2022-12-14 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Insights into distinct signaling profiles of the mu OR activated by diverse agonists. Nat.Chem.Biol., 2022
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7T2G
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![BU of 7t2g by Molmil](/molmil-images/mine/7t2g) | CryoEM structure of mu-opioid receptor - Gi protein complex bound to mitragynine pseudoindoxyl (MP) | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Seven, A.B, Qu, Q, Robertson, M.J, Wang, H, Kobilka, B.K, Skiniotis, G. | 登録日 | 2021-12-04 | 公開日 | 2022-12-07 | 最終更新日 | 2023-02-15 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Insights into distinct signaling profiles of the mu OR activated by diverse agonists. Nat.Chem.Biol., 2022
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7T90
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![BU of 7t90 by Molmil](/molmil-images/mine/7t90) | Cryo-EM structure of ACh-bound M2R-Go signaling complex in S2 state | 分子名称: | ACETYLCHOLINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, J, Wang, Q, Du, Y, Kobilka, B.K. | 登録日 | 2021-12-17 | 公開日 | 2023-01-25 | 最終更新日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor. Nat Commun, 14, 2023
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7T8X
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![BU of 7t8x by Molmil](/molmil-images/mine/7t8x) | Cryo-EM structure of ACh-bound M2R-Go signaling complex in S1 state | 分子名称: | ACETYLCHOLINE, Antibody fragment, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Xu, J, Wang, Q, Du, Y, Kobilka, B.K. | 登録日 | 2021-12-17 | 公開日 | 2023-01-25 | 最終更新日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | 主引用文献 | Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor. Nat Commun, 14, 2023
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7T96
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![BU of 7t96 by Molmil](/molmil-images/mine/7t96) | Cryo-EM structure of S2 state ACh-bound M2R-Go signaling complex with a PAM | 分子名称: | 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, ACETYLCHOLINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Xu, J, Wang, Q, Du, Y, Kobilka, B.K. | 登録日 | 2021-12-18 | 公開日 | 2023-01-25 | 最終更新日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor. Nat Commun, 14, 2023
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7T94
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![BU of 7t94 by Molmil](/molmil-images/mine/7t94) | Cryo-EM structure of S1 state ACh-bound M2R-Go signaling complex with a PAM | 分子名称: | 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, ACETYLCHOLINE, Antibody fragment, ... | 著者 | Xu, J, Wang, Q, Du, Y, Kobilka, B.K. | 登録日 | 2021-12-17 | 公開日 | 2023-01-25 | 最終更新日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | 主引用文献 | Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor. Nat Commun, 14, 2023
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7U2L
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![BU of 7u2l by Molmil](/molmil-images/mine/7u2l) | C5guano-uOR-Gi-scFv16 | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Wang, H, Qu, Q, Skiniotis, G, Kobilka, B. | 登録日 | 2022-02-24 | 公開日 | 2022-05-04 | 最終更新日 | 2023-02-08 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structure-based design of bitopic ligands for the μ-opioid receptor. Nature, 613, 2023
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7U2K
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![BU of 7u2k by Molmil](/molmil-images/mine/7u2k) | C6-guano bound Mu Opioid Receptor-Gi Protein Complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Wang, H, Kobilka, B. | 登録日 | 2022-02-24 | 公開日 | 2022-12-07 | 最終更新日 | 2023-02-08 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure-based design of bitopic ligands for the μ-opioid receptor. Nature, 613, 2023
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7TMW
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![BU of 7tmw by Molmil](/molmil-images/mine/7tmw) | Cryo-EM structure of the relaxin receptor RXFP1 in complex with heterotrimeric Gs | 分子名称: | Camelid antibody VHH fragment Nb35, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Erlandson, S.C, Rawson, S, Kruse, A.C. | 登録日 | 2022-01-20 | 公開日 | 2023-02-15 | 最終更新日 | 2023-08-09 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | The relaxin receptor RXFP1 signals through a mechanism of autoinhibition. Nat.Chem.Biol., 19, 2023
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7SRR
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![BU of 7srr by Molmil](/molmil-images/mine/7srr) | 5-HT2B receptor bound to LSD in complex with heterotrimeric mini-Gq protein obtained by cryo-electron microscopy (cryoEM) | 分子名称: | (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, 5-hydroxytryptamine receptor 2B, G protein subunit q (Gi2-mini-Gq chimera), ... | 著者 | Barros-Alvarez, X, Kim, K, Panova, O, Cao, C, Roth, B.L, Skiniotis, G. | 登録日 | 2021-11-08 | 公開日 | 2022-09-21 | 最終更新日 | 2022-10-19 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD. Neuron, 110, 2022
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7TRK
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![BU of 7trk by Molmil](/molmil-images/mine/7trk) | Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo | 分子名称: | 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Antibody fragment scFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. | 登録日 | 2022-01-29 | 公開日 | 2023-05-17 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor Elife, 2023
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7TRP
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![BU of 7trp by Molmil](/molmil-images/mine/7trp) | Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator LY2033298 | 分子名称: | 3-amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Antibody fragment scFv16, ... | 著者 | Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. | 登録日 | 2022-01-30 | 公開日 | 2023-05-17 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor Elife, 2023
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7TRQ
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![BU of 7trq by Molmil](/molmil-images/mine/7trq) | Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator VU0467154 | 分子名称: | 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, 5-amino-3,4-dimethyl-N-{[4-(trifluoromethanesulfonyl)phenyl]methyl}thieno[2,3-c]pyridazine-6-carboxamide, Antibody fragment scFv16, ... | 著者 | Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. | 登録日 | 2022-01-30 | 公開日 | 2023-05-17 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor Elife, 2023
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7TRS
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![BU of 7trs by Molmil](/molmil-images/mine/7trs) | Human M4 muscarinic acetylcholine receptor complex with Gi1 and the endogenous agonist acetylcholine | 分子名称: | ACETYLCHOLINE, Antibody fragment scFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. | 登録日 | 2022-01-30 | 公開日 | 2023-05-17 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor Elife, 2023
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7TD0
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![BU of 7td0 by Molmil](/molmil-images/mine/7td0) | Lysophosphatidic acid receptor 1-Gi complex bound to LPA | 分子名称: | (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Liu, S, Paknejad, N, Zhu, L, Kihara, Y, Ray, D, Chun, J, Liu, W, Hite, R.K, Huang, X.Y. | 登録日 | 2021-12-30 | 公開日 | 2022-02-09 | 最終更新日 | 2022-02-23 | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | 主引用文献 | Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate. Nat Commun, 13, 2022
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7TD2
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![BU of 7td2 by Molmil](/molmil-images/mine/7td2) | Lysophosphatidic acid receptor 1-Gi complex bound to LPA, state a | 分子名称: | (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Liu, S, Paknejad, N, Zhu, L, Kihara, Y, Ray, D, Chun, J, Liu, W, Hite, R.K, Huang, X.Y. | 登録日 | 2021-12-30 | 公開日 | 2022-02-09 | 最終更新日 | 2022-02-23 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate. Nat Commun, 13, 2022
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7TD3
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![BU of 7td3 by Molmil](/molmil-images/mine/7td3) | Sphingosine-1-phosphate receptor 1-Gi complex bound to S1P | 分子名称: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Liu, S, Paknejad, N, Zhu, L, Kihara, Y, Ray, D, Chun, J, Liu, W, Hite, R.K, Huang, X.Y. | 登録日 | 2021-12-30 | 公開日 | 2022-02-09 | 最終更新日 | 2022-02-23 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate. Nat Commun, 13, 2022
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7TD1
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![BU of 7td1 by Molmil](/molmil-images/mine/7td1) | Lysophosphatidic acid receptor 1-Gi complex bound to LPA, state a | 分子名称: | (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Liu, S, Paknejad, N, Zhu, L, Kihara, Y, Ray, D, Chun, J, Liu, W, Hite, R.K, Huang, X.Y. | 登録日 | 2021-12-30 | 公開日 | 2022-02-09 | 最終更新日 | 2022-02-23 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate. Nat Commun, 13, 2022
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