7T9M

Human Thyrotropin receptor bound by CS-17 Inverse Agonist Fab/Org 274179-0 Antagonist

Summary for 7T9M

• Entry DOI: 10.2210/pdb7t9m/pdb
• EMDB information: 25762
• Descriptor: CS-17 Heavy Chain, CS-17 Light Chain, Thyrotropin receptor, ... (5 entities in total)
• Functional Keywords: g protein-coupled receptor, thyroid-stimulating hormone receptor, thyrotropin receptor, cs-17 fab, thyroid, membrane protein
• Biological source: Mus musculus (mouse); More
• Total number of polymer chains: 3
• Total formula weight: 127392.03

Authors

Faust, B.,Cheng, Y.,Manglik, A. (deposition date: 2021-12-19, release date: 2022-08-10, Last modification date: 2022-10-05)

• Primary citation: Faust, B.,Billesbolle, C.B.,Suomivuori, C.M.,Singh, I.,Zhang, K.,Hoppe, N.,Pinto, A.F.M.,Diedrich, J.K.,Muftuoglu, Y.,Szkudlinski, M.W.,Saghatelian, A.,Dror, R.O.,Cheng, Y.,Manglik, A.; Autoantibody mimicry of hormone action at the thyrotropin receptor.; Nature, 609:846-853, 2022; PubMed: 35940205; DOI: 10.1038/s41586-022-05159-1

Experimental method

ELECTRON MICROSCOPY (3.1 Å)