7T9M
Human Thyrotropin receptor bound by CS-17 Inverse Agonist Fab/Org 274179-0 Antagonist
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | CS-17 Heavy Chain | polymer | 217 | 23277.9 | 1 | Mus musculus (mouse) | ||
| 2 | B (L) | CS-17 Light Chain | polymer | 213 | 23283.7 | 1 | Mus musculus (mouse) | ||
| 3 | C (R) | Thyrotropin receptor | polymer | 702 | 79742.4 | 1 | UniProt (A0A0A0MTJ0) Pfam (PF13306) Pfam (PF00001) UniProt (by SIFTS) (P16473) | Homo sapiens (human) | |
| 4 | D (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | E, F, G (R) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) |
Sequence modifications
R: 22 - 764 (UniProt: A0A0A0MTJ0)
| PDB | External Database | Details |
|---|---|---|
| Asp 13 | - | expression tag |
| Tyr 14 | - | expression tag |
| Lys 15 | - | expression tag |
| Asp 16 | - | expression tag |
| Asp 17 | - | expression tag |
| Asp 18 | - | expression tag |
| Asp 19 | - | expression tag |
| Gly 20 | - | expression tag |
| Thr 21 | - | expression tag |
| - | Ala 317 | deletion |
| - | Leu 318 | deletion |
| - | Asn 319 | deletion |
| - | Ser 320 | deletion |
| - | Pro 321 | deletion |
| - | Leu 322 | deletion |
| - | His 323 | deletion |
| - | Gln 324 | deletion |
| - | Glu 325 | deletion |
| - | Tyr 326 | deletion |
| - | Glu 327 | deletion |
| - | Glu 328 | deletion |
| - | Asn 329 | deletion |
| - | Leu 330 | deletion |
| - | Gly 331 | deletion |
| - | Asp 332 | deletion |
| - | Ser 333 | deletion |
| - | Ile 334 | deletion |
| - | Val 335 | deletion |
| - | Gly 336 | deletion |
| - | Tyr 337 | deletion |
| - | Lys 338 | deletion |
| - | Glu 339 | deletion |
| - | Lys 340 | deletion |
| - | Ser 341 | deletion |
| - | Lys 342 | deletion |
| - | Phe 343 | deletion |
| - | Gln 344 | deletion |
| - | Asp 345 | deletion |
| - | Thr 346 | deletion |
| - | His 347 | deletion |
| - | Asn 348 | deletion |
| - | Asn 349 | deletion |
| - | Ala 350 | deletion |
| - | His 351 | deletion |
| - | Tyr 352 | deletion |
| - | Tyr 353 | deletion |
| - | Val 354 | deletion |
| - | Phe 355 | deletion |
| - | Phe 356 | deletion |
| - | Glu 357 | deletion |
| - | Glu 358 | deletion |
| - | Gln 359 | deletion |
| - | Glu 360 | deletion |
| - | Asp 361 | deletion |
| - | Glu 362 | deletion |
| - | Ile 363 | deletion |
| - | Ile 364 | deletion |
| - | Gly 365 | deletion |
| - | Phe 366 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 126304.0 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 663.6 | |
| All* | Total formula weight | 127392.0 |
