7T32

CryoEM structure of the adenosine 2A receptor-BRIL/Anti BRIL Fab complex with ZM241385

Summary for 7T32

• Entry DOI: 10.2210/pdb7t32/pdb
• EMDB information: 25648
• Descriptor: Adenosine receptor A2a/Soluble cytochrome b562 Fusion Protein, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol (2 entities in total)
• Functional Keywords: a2aar, gpcr, adenosine receptor, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 43753.19

Authors

Zhang, K.H.,Wu, H.,Hoppe, N.,Manglik, A.,Cheng, Y.F. (deposition date: 2021-12-06, release date: 2022-08-10)

• Primary citation: Zhang, K.,Wu, H.,Hoppe, N.,Manglik, A.,Cheng, Y.; Fusion protein strategies for cryo-EM study of G protein-coupled receptors.; Nat Commun, 13:4366-4366, 2022; PubMed: 35902590; DOI: 10.1038/s41467-022-32125-2

Experimental method

ELECTRON MICROSCOPY (3.4 Å)