7T32

CryoEM structure of the adenosine 2A receptor-BRIL/Anti BRIL Fab complex with ZM241385

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Adenosine receptor A2a/Soluble cytochrome b562 Fusion Protein	polymer	391	43415.9	1	UniProt (P29274) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361)	Homo sapiens (human)	Cytochrome b-562
2	B (A)	4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol	non-polymer		337.3	1	Chemie (ZMA)

Sequence modifications

A: 8 - 208 (UniProt: P29274)
A: 209 - 314 (UniProt: P0ABE7)

PDB	External Database	Details
Trp 215	Met 29	conflict
Ile 310	His 124	conflict
Leu 314	Arg 128	conflict

A: 315 - 398 (UniProt: P29274)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	43415.9
Non-Polymers*	Number of molecules	1
	Total formula weight	337.3
All*	Total formula weight	43753.2

*Water molecules are not included.