7T9N

M22 Agonist Autoantibody bound to Human Thyrotropin receptor in complex with miniGs399 (composite structure)

Summary for 7T9N

• Entry DOI: 10.2210/pdb7t9n/pdb
• EMDB information: 25763
• Descriptor: M22 Fab light chain, M22 Fab heavy chain, Nanobody 35, ... (9 entities in total)
• Functional Keywords: g protein-coupled receptor, thyrotropin receptor, thyroid, m22, autoantibody, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 7
• Total formula weight: 227413.69

Authors

Faust, B.,Cheng, Y.,Manglik, A. (deposition date: 2021-12-19, release date: 2022-08-03, Last modification date: 2022-10-05)

• Primary citation: Faust, B.,Billesbolle, C.B.,Suomivuori, C.M.,Singh, I.,Zhang, K.,Hoppe, N.,Pinto, A.F.M.,Diedrich, J.K.,Muftuoglu, Y.,Szkudlinski, M.W.,Saghatelian, A.,Dror, R.O.,Cheng, Y.,Manglik, A.; Autoantibody mimicry of hormone action at the thyrotropin receptor.; Nature, 609:846-853, 2022; PubMed: 35940205; DOI: 10.1038/s41586-022-05159-1

Experimental method

ELECTRON MICROSCOPY (2.9 Å)