7TD3

Sphingosine-1-phosphate receptor 1-Gi complex bound to S1P

Summary for 7TD3

Entry DOI	10.2210/pdb7td3/pdb
EMDB information	25822
Descriptor	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
Functional Keywords	gpcr, complex, lipid, membrane protein
Biological source	Bos taurus (cattle) More
Total number of polymer chains	4
Total formula weight	132964.49
Authors	Liu, S.,Paknejad, N.,Zhu, L.,Kihara, Y.,Ray, D.,Chun, J.,Liu, W.,Hite, R.K.,Huang, X.Y. (deposition date: 2021-12-30, release date: 2022-02-09, Last modification date: 2022-02-23)
Primary citation	Liu, S.,Paknejad, N.,Zhu, L.,Kihara, Y.,Ray, M.,Chun, J.,Liu, W.,Hite, R.K.,Huang, X.Y. Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate. Nat Commun, 13:731-731, 2022 Cited by PubMed: 35136060 DOI: 10.1038/s41467-022-28417-2 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3 Å)

Structure validation