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7TD3

Sphingosine-1-phosphate receptor 1-Gi complex bound to S1P

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001664molecular_functionG protein-coupled receptor binding
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005834cellular_componentheterotrimeric G-protein complex
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005938cellular_componentcell cortex
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0019001molecular_functionguanyl nucleotide binding
A0019003molecular_functionGDP binding
A0030496cellular_componentmidbody
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031749molecular_functionD2 dopamine receptor binding
A0031821molecular_functionG protein-coupled serotonin receptor binding
A0032794molecular_functionGTPase activating protein binding
A0032991cellular_componentprotein-containing complex
A0043949biological_processregulation of cAMP-mediated signaling
A0046872molecular_functionmetal ion binding
A0050805biological_processnegative regulation of synaptic transmission
A0051301biological_processcell division
A0060236biological_processregulation of mitotic spindle organization
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099645biological_processneurotransmitter receptor localization to postsynaptic specialization membrane
A1904322biological_processcellular response to forskolin
A1904778biological_processpositive regulation of protein localization to cell cortex
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005834cellular_componentheterotrimeric G-protein complex
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
G0003924molecular_functionGTPase activity
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
R0001525biological_processangiogenesis
R0001664molecular_functionG protein-coupled receptor binding
R0001955biological_processblood vessel maturation
R0003245biological_processcardiac muscle tissue growth involved in heart morphogenesis
R0003376biological_processsphingosine-1-phosphate receptor signaling pathway
R0004930molecular_functionG protein-coupled receptor activity
R0005515molecular_functionprotein binding
R0005654cellular_componentnucleoplasm
R0005737cellular_componentcytoplasm
R0005768cellular_componentendosome
R0005886cellular_componentplasma membrane
R0006935biological_processchemotaxis
R0007155biological_processcell adhesion
R0007186biological_processG protein-coupled receptor signaling pathway
R0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
R0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
R0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
R0007420biological_processbrain development
R0008283biological_processcell population proliferation
R0008284biological_processpositive regulation of cell population proliferation
R0009897cellular_componentexternal side of plasma membrane
R0016020cellular_componentmembrane
R0016477biological_processcell migration
R0019222biological_processregulation of metabolic process
R0019226biological_processtransmission of nerve impulse
R0030032biological_processlamellipodium assembly
R0030036biological_processactin cytoskeleton organization
R0030155biological_processregulation of cell adhesion
R0030182biological_processneuron differentiation
R0030335biological_processpositive regulation of cell migration
R0030500biological_processregulation of bone mineralization
R0030595biological_processleukocyte chemotaxis
R0038036molecular_functionsphingosine-1-phosphate receptor activity
R0043231cellular_componentintracellular membrane-bounded organelle
R0045121cellular_componentmembrane raft
R0045124biological_processregulation of bone resorption
R0045446biological_processendothelial cell differentiation
R0045944biological_processpositive regulation of transcription by RNA polymerase II
R0046625molecular_functionsphingolipid binding
R0048661biological_processpositive regulation of smooth muscle cell proliferation
R0050927biological_processpositive regulation of positive chemotaxis
R0051497biological_processnegative regulation of stress fiber assembly
R0061384biological_processheart trabecula morphogenesis
R0072678biological_processT cell migration
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASVfSLLAIAIERYItM
ChainResidueDetails
RALA130-MET146

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues21
DetailsTRANSMEM: Helical; Name=1
ChainResidueDetails
RLEU47-LEU68
ALEU175
AASP200
AASN269

site_idSWS_FT_FI2
Number of Residues137
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:15750791
ChainResidueDetails
RTHR69-TYR82
RALA139-LEU160
RTYR225-THR257
RTYR311-SER382

site_idSWS_FT_FI3
Number of Residues21
DetailsTRANSMEM: Helical; Name=2
ChainResidueDetails
RPHE83-LEU104

site_idSWS_FT_FI4
Number of Residues34
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:15750791
ChainResidueDetails
RSER105-GLN116
RASN183-PRO196
RASP279-ILE289

site_idSWS_FT_FI5
Number of Residues21
DetailsTRANSMEM: Helical; Name=3
ChainResidueDetails
RTRP117-ILE138

site_idSWS_FT_FI6
Number of Residues21
DetailsTRANSMEM: Helical; Name=4
ChainResidueDetails
RPHE161-TRP182

site_idSWS_FT_FI7
Number of Residues27
DetailsTRANSMEM: Helical; Name=5
ChainResidueDetails
RLEU197-ILE224

site_idSWS_FT_FI8
Number of Residues20
DetailsTRANSMEM: Helical; Name=6
ChainResidueDetails
RVAL258-LEU278

site_idSWS_FT_FI9
Number of Residues20
DetailsTRANSMEM: Helical; Name=7
ChainResidueDetails
RLEU290-ILE310

site_idSWS_FT_FI10
Number of Residues2
DetailsBINDING:
ChainResidueDetails
RARG120
RPHE265

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:O08530
ChainResidueDetails
RLYS10

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by PKB/AKT1 => ECO:0000269|PubMed:11583630
ChainResidueDetails
RTHR236

site_idSWS_FT_FI13
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O08530
ChainResidueDetails
RSER351

site_idSWS_FT_FI14
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000255
ChainResidueDetails
RSER353

site_idSWS_FT_FI15
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250
ChainResidueDetails
RCYS328

site_idSWS_FT_FI16
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15750791, ECO:0000269|PubMed:22344443
ChainResidueDetails
RASN30

site_idSWS_FT_FI17
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN36

Catalytic Information from CSA
site_idMCSA1
Number of Residues5
DetailsM-CSA 533
ChainResidueDetails
AGLU43electrostatic stabiliser
ATHR48electrostatic stabiliser
AARG178electrostatic stabiliser
AASP200electrostatic stabiliser
AGLN204electrostatic stabiliser

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PDB entries from 2024-07-24

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