7VDL
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7VDH
| Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state2 | 分子名称: | 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{N}-methyl-ethanamine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Li, Y, Yang, F. | 登録日 | 2021-09-07 | 公開日 | 2021-12-01 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structure, function and pharmacology of human itch receptor complexes. Nature, 600, 2021
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7V6A
| Cry-EM structure of M4-c110-G protein complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Wang, J.J, Wu, M, Wu, L.J, Hua, T, Liu, Z.J, Wang, T. | 登録日 | 2021-08-20 | 公開日 | 2022-05-11 | 最終更新日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands. Nat Commun, 13, 2022
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7V69
| Cryo-EM structure of a class A GPCR-G protein complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Wang, J.J, Wu, M, Wu, L.J, Hua, T, Liu, Z.J, Wang, T. | 登録日 | 2021-08-20 | 公開日 | 2022-05-11 | 最終更新日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands. Nat Commun, 13, 2022
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7V68
| An Agonist and PAM-bound Class A GPCR with Gi protein complex structure | 分子名称: | 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Wang, J.J, Wu, L.J, Wu, M, Hua, T, Liu, Z.J, Wang, T. | 登録日 | 2021-08-20 | 公開日 | 2022-05-11 | 最終更新日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands. Nat Commun, 13, 2022
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7V3Z
| Structure of cannabinoid receptor type 1(CB1) | 分子名称: | 2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol, CHOLESTEROL, FLAVIN MONONUCLEOTIDE, ... | 著者 | Liu, Z.J, Shen, L, Hua, T, Yao, D.Q, Wu, L.J. | 登録日 | 2021-08-12 | 公開日 | 2021-11-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.29 Å) | 主引用文献 | A Genetically Encoded F-19 NMR Probe Reveals the Allosteric Modulation Mechanism of Cannabinoid Receptor 1. J.Am.Chem.Soc., 143, 2021
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7UTZ
| Human thyrotropin analog TR1402 bound to human Thyrotropin receptor in complex with miniGs399 (composite structure) | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein hormones alpha chain analog TR1402, ... | 著者 | Faust, B, Cheng, Y, Manglik, A. | 登録日 | 2022-04-28 | 公開日 | 2022-08-03 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Autoantibody mimicry of hormone action at the thyrotropin receptor. Nature, 609, 2022
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7UM7
| CryoEM structure of Go-coupled 5-HT5AR in complex with Methylergometrine | 分子名称: | (8beta)-N-[(2S)-1-hydroxybutan-2-yl]-6-methyl-9,10-didehydroergoline-8-carboxamide, 5-hydroxytryptamine receptor 5A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Zhang, S, Fay, J.F, Roth, B.L. | 登録日 | 2022-04-06 | 公開日 | 2022-07-20 | 最終更新日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (2.75 Å) | 主引用文献 | Inactive and active state structures template selective tools for the human 5-HT 5A receptor. Nat.Struct.Mol.Biol., 29, 2022
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7UM6
| CryoEM structure of Go-coupled 5-HT5AR in complex with Lisuride | 分子名称: | 5-hydroxytryptamine receptor 5A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhang, S, Fay, J.F, Roth, B.L. | 登録日 | 2022-04-06 | 公開日 | 2022-07-20 | 最終更新日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | 主引用文献 | Inactive and active state structures template selective tools for the human 5-HT 5A receptor. Nat.Struct.Mol.Biol., 29, 2022
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7UM5
| CryoEM structure of Go-coupled 5-HT5AR in complex with 5-CT | 分子名称: | 3-(2-azanylethyl)-1H-indole-5-carboxamide, 5-hydroxytryptamine receptor 5A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Zhang, S, Fay, J.F, Roth, B.L. | 登録日 | 2022-04-06 | 公開日 | 2022-07-20 | 最終更新日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (2.73 Å) | 主引用文献 | Inactive and active state structures template selective tools for the human 5-HT 5A receptor. Nat.Struct.Mol.Biol., 29, 2022
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7UM4
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7UL5
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7UL4
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7UL3
| CryoEM Structure of Inactive H2R Bound to Famotidine, Nb6M, and NabFab | 分子名称: | Histamine H2 receptor, NabFab HC, NabFab LC, ... | 著者 | Robertson, M.J, Skiniotis, G. | 登録日 | 2022-04-03 | 公開日 | 2022-06-29 | 最終更新日 | 2022-12-28 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure determination of inactive-state GPCRs with a universal nanobody. Nat.Struct.Mol.Biol., 29, 2022
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7UL2
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7U2L
| C5guano-uOR-Gi-scFv16 | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Wang, H, Qu, Q, Skiniotis, G, Kobilka, B. | 登録日 | 2022-02-24 | 公開日 | 2022-05-04 | 最終更新日 | 2023-02-08 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structure-based design of bitopic ligands for the μ-opioid receptor. Nature, 613, 2023
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7U2K
| C6-guano bound Mu Opioid Receptor-Gi Protein Complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Wang, H, Kobilka, B. | 登録日 | 2022-02-24 | 公開日 | 2022-12-07 | 最終更新日 | 2023-02-08 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure-based design of bitopic ligands for the μ-opioid receptor. Nature, 613, 2023
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7TUZ
| Cryo-EM structure of 7alpha,25-dihydroxycholesterol-bound EBI2/GPR183 in complex with Gi protein | 分子名称: | (2S,4aS,4bS,7R,8S,8aS,9R,10aR)-7-[(2R,3R)-7-hydroxy-3,7-dimethyloctan-2-yl]-4a,7,8-trimethyltetradecahydrophenanthrene-2,9-diol, G-protein coupled receptor 183, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Chen, H, Hung, W, Li, X. | 登録日 | 2022-02-03 | 公開日 | 2022-04-13 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response. Structure, 30, 2022
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7TUY
| Cryo-EM structure of GSK682753A-bound EBI2/GPR183 | 分子名称: | 8-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]-3-[(3,4-dichlorophenyl)methyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one, G-protein coupled receptor 183,Soluble cytochrome b562 fusion, anti-BRIL Fab Heavy chain, ... | 著者 | Chen, H, Huang, W, Li, X. | 登録日 | 2022-02-03 | 公開日 | 2022-04-13 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response. Structure, 30, 2022
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7TRS
| Human M4 muscarinic acetylcholine receptor complex with Gi1 and the endogenous agonist acetylcholine | 分子名称: | ACETYLCHOLINE, Antibody fragment scFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. | 登録日 | 2022-01-30 | 公開日 | 2023-05-17 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor Elife, 2023
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7TRQ
| Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator VU0467154 | 分子名称: | 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, 5-amino-3,4-dimethyl-N-{[4-(trifluoromethanesulfonyl)phenyl]methyl}thieno[2,3-c]pyridazine-6-carboxamide, Antibody fragment scFv16, ... | 著者 | Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. | 登録日 | 2022-01-30 | 公開日 | 2023-05-17 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor Elife, 2023
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7TRP
| Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator LY2033298 | 分子名称: | 3-amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Antibody fragment scFv16, ... | 著者 | Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. | 登録日 | 2022-01-30 | 公開日 | 2023-05-17 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor Elife, 2023
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7TRK
| Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo | 分子名称: | 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Antibody fragment scFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. | 登録日 | 2022-01-29 | 公開日 | 2023-05-17 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor Elife, 2023
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7TMW
| Cryo-EM structure of the relaxin receptor RXFP1 in complex with heterotrimeric Gs | 分子名称: | Camelid antibody VHH fragment Nb35, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Erlandson, S.C, Rawson, S, Kruse, A.C. | 登録日 | 2022-01-20 | 公開日 | 2023-02-15 | 最終更新日 | 2023-08-09 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | The relaxin receptor RXFP1 signals through a mechanism of autoinhibition. Nat.Chem.Biol., 19, 2023
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7TD4
| Sphingosine-1-phosphate receptor 1-Gi complex bound to Siponimod | 分子名称: | 1-[[4-[(~{E})-~{N}-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-~{C}-methyl-carbonimidoyl]-2-ethyl-phenyl]methyl]azetidine-3-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Liu, S, Paknejad, N, Zhu, L, Kihara, Y, Ray, D, Chun, J, Liu, W, Hite, R.K, Huang, X.Y. | 登録日 | 2021-12-30 | 公開日 | 2022-02-09 | 最終更新日 | 2022-02-23 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate. Nat Commun, 13, 2022
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