4ZPR
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![BU of 4zpr by Molmil](/molmil-images/mine/4zpr) | Crystal Structure of the Heterodimeric HIF-1a:ARNT Complex with HRE DNA | 分子名称: | Aryl hydrocarbon receptor nuclear translocator, DNA (5'-D(*CP*AP*CP*GP*AP*CP*CP*CP*GP*CP*AP*CP*GP*TP*AP*CP*GP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*GP*CP*TP*GP*CP*GP*TP*AP*CP*GP*TP*GP*CP*GP*GP*GP*TP*CP*GP*T)-3'), ... | 著者 | Wu, D, Potluri, N, Lu, J, Kim, Y, Rastinejad, F. | 登録日 | 2015-05-08 | 公開日 | 2015-08-12 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.902 Å) | 主引用文献 | Structural integration in hypoxia-inducible factors. Nature, 524, 2015
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4ZQD
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![BU of 4zqd by Molmil](/molmil-images/mine/4zqd) | Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex with the Benzoxadiazole Antagonist 0X3 | 分子名称: | Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine | 著者 | Wu, D, Potluri, N, Lu, J, Kim, Y, Rastinejad, F. | 登録日 | 2015-05-09 | 公開日 | 2015-08-12 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.87 Å) | 主引用文献 | Structural integration in hypoxia-inducible factors. Nature, 524, 2015
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5EYO
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![BU of 5eyo by Molmil](/molmil-images/mine/5eyo) | The crystal structure of the Max bHLH domain in complex with 5-carboxyl cytosine DNA | 分子名称: | DNA (5'-D(*AP*GP*TP*AP*GP*CP*AP*(1CC)P*GP*TP*GP*CP*TP*AP*CP*T)-3'), Protein max | 著者 | Wang, D, Hashimoto, H, Zhang, X, Cheng, X. | 登録日 | 2015-11-25 | 公開日 | 2016-12-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | MAX is an epigenetic sensor of 5-carboxylcytosine and is altered in multiple myeloma. Nucleic Acids Res., 45, 2017
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5GNJ
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![BU of 5gnj by Molmil](/molmil-images/mine/5gnj) | Structure of a transcription factor and DNA complex | 分子名称: | DNA (5'-D(*AP*GP*GP*AP*AP*CP*AP*CP*GP*TP*GP*AP*CP*CP*C)-3'), DNA (5'-D(*TP*GP*GP*GP*TP*CP*AP*CP*GP*TP*GP*TP*TP*CP*C)-3'), Transcription factor MYC2 | 著者 | Lian, T, Xu, Y, Su, X. | 登録日 | 2016-07-21 | 公開日 | 2017-05-10 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal Structure of Tetrameric Arabidopsis MYC2 Reveals the Mechanism of Enhanced Interaction with DNA. Cell Rep, 19, 2017
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5I4Z
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![BU of 5i4z by Molmil](/molmil-images/mine/5i4z) | Structure of apo OmoMYC | 分子名称: | CHLORIDE ION, GLYCEROL, Myc proto-oncogene protein, ... | 著者 | Koelmel, W, Jung, L.A, Kuper, J, Eilers, M, Kisker, C. | 登録日 | 2016-02-13 | 公開日 | 2016-10-26 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors. Oncogene, 36, 2017
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5I50
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![BU of 5i50 by Molmil](/molmil-images/mine/5i50) | Structure of OmoMYC bound to double-stranded DNA | 分子名称: | DNA (5'-D(P*CP*AP*CP*CP*CP*GP*GP*TP*CP*AP*CP*GP*TP*GP*GP*CP*CP*TP*AP*CP*AP*C)-3'), DNA (5'-D(P*GP*TP*GP*TP*AP*GP*GP*CP*CP*AP*CP*GP*TP*GP*AP*CP*CP*GP*GP*GP*TP*G)-3'), Myc proto-oncogene protein | 著者 | Koelmel, W, Jung, L.A, Kuper, J, Eilers, M, Kisker, C. | 登録日 | 2016-02-13 | 公開日 | 2016-10-26 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.701 Å) | 主引用文献 | OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors. Oncogene, 36, 2017
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5NJ8
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![BU of 5nj8 by Molmil](/molmil-images/mine/5nj8) | |
5SY5
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![BU of 5sy5 by Molmil](/molmil-images/mine/5sy5) | Crystal Structure of the Heterodimeric NPAS1-ARNT Complex | 分子名称: | Aryl hydrocarbon receptor nuclear translocator, Neuronal PAS domain-containing protein 1 | 著者 | Wu, D, Su, X, Potluri, N, Kim, Y, Rastinejad, F. | 登録日 | 2016-08-10 | 公開日 | 2016-11-09 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.201 Å) | 主引用文献 | NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors. Elife, 5, 2016
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5SY7
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![BU of 5sy7 by Molmil](/molmil-images/mine/5sy7) | Crystal Structure of the Heterodimeric NPAS3-ARNT Complex with HRE DNA | 分子名称: | Aryl hydrocarbon receptor nuclear translocator, DNA (5'-D(*CP*AP*CP*GP*AP*CP*CP*CP*GP*CP*AP*CP*GP*TP*AP*CP*GP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*GP*CP*TP*GP*CP*GP*TP*AP*CP*GP*TP*GP*CP*GP*GP*GP*TP*CP*GP*T)-3'), ... | 著者 | Wu, D, Su, X, Potluri, N, Kim, Y, Rastinejad, F. | 登録日 | 2016-08-10 | 公開日 | 2016-11-09 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | 主引用文献 | NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors. Elife, 5, 2016
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5V0L
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![BU of 5v0l by Molmil](/molmil-images/mine/5v0l) | Crystal structure of the AHR-ARNT heterodimer in complex with the DRE | 分子名称: | Aryl hydrocarbon receptor, Aryl hydrocarbon receptor nuclear translocator, CITRIC ACID, ... | 著者 | Seok, S.-H, Lee, W, Jiang, L, Bradfield, C.A, Xing, Y. | 登録日 | 2017-02-28 | 公開日 | 2017-04-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (4 Å) | 主引用文献 | Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5Y7Y
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![BU of 5y7y by Molmil](/molmil-images/mine/5y7y) | Crystal structure of AhRR/ARNT complex | 分子名称: | Aryl hydrocarbon receptor nuclear translocator, Aryl hydrocarbon receptor repressor, GLYCEROL | 著者 | Sakurai, S, Shimizu, T, Ohto, U. | 登録日 | 2017-08-18 | 公開日 | 2017-09-20 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | The crystal structure of the AhRR-ARNT heterodimer reveals the structural basis of the repression of AhR-mediated transcription. J. Biol. Chem., 292, 2017
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6E3S
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![BU of 6e3s by Molmil](/molmil-images/mine/6e3s) | Crystal Structure of the Heterodimeric HIF-2 Complex with Antagonist PT2385 | 分子名称: | 3-{[(1S)-2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 | 著者 | Wu, D, Su, X, Lu, J, Li, S, Hood, B, Vasile, S, Potluri, N, Diao, X, Kim, Y, Khorasanizadeh, S, Rastinejad, F. | 登録日 | 2018-07-15 | 公開日 | 2019-02-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Bidirectional modulation of HIF-2 activity through chemical ligands. Nat. Chem. Biol., 15, 2019
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6E3T
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![BU of 6e3t by Molmil](/molmil-images/mine/6e3t) | Crystal Structure of the Heterodimeric HIF-2 Complex with Antagonist T1001 | 分子名称: | (6S)-6-(4-bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 | 著者 | Wu, D, Su, X, Lu, J, Li, S, Hood, B, Vasile, S, Potluri, N, Diao, X, Kim, Y, Khorasanizadeh, S, Rastinejad, F. | 登録日 | 2018-07-15 | 公開日 | 2019-02-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Bidirectional modulation of HIF-2 activity through chemical ligands. Nat. Chem. Biol., 15, 2019
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6E3U
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![BU of 6e3u by Molmil](/molmil-images/mine/6e3u) | Crystal Structure of the Heterodimeric HIF-2 Complex with Agonist M1001 | 分子名称: | 3-{[2-(pyrrolidin-1-yl)phenyl]amino}-1H-1lambda~6~,2-benzothiazole-1,1-dione, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 | 著者 | Wu, D, Su, X, Lu, J, Li, S, Hood, B, Vasile, S, Potluri, N, Diao, X, Kim, Y, Khorasanizadeh, S, Rastinejad, F. | 登録日 | 2018-07-15 | 公開日 | 2019-02-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Bidirectional modulation of HIF-2 activity through chemical ligands. Nat. Chem. Biol., 15, 2019
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6FX5
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![BU of 6fx5 by Molmil](/molmil-images/mine/6fx5) | MITF dimerization mutant | 分子名称: | Microphthalmia-associated transcription factor, SULFATE ION | 著者 | Pogenberg, V, Milewski, M, Wilmanns, M. | 登録日 | 2018-03-08 | 公開日 | 2019-03-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Mechanism of conditional partner selectivity in MITF/TFE family transcription factors with a conserved coiled coil stammer motif. Nucleic Acids Res., 48, 2020
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6G1L
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![BU of 6g1l by Molmil](/molmil-images/mine/6g1l) | MITF/CLEARbox structure | 分子名称: | CLEAR-box, Microphthalmia-associated transcription factor | 著者 | Pogenberg, V, Wilmanns, M. | 登録日 | 2018-03-21 | 公開日 | 2019-02-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | MITF has a central role in regulating starvation-induced autophagy in melanoma. Sci Rep, 9, 2019
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6G6J
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![BU of 6g6j by Molmil](/molmil-images/mine/6g6j) | The crystal structures of Human MYC:MAX bHLHZip complex | 分子名称: | Myc proto-oncogene protein, Protein max, SULFATE ION | 著者 | Allen, M.D, Zinzalla, G. | 登録日 | 2018-04-01 | 公開日 | 2019-04-10 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Crystal Structures and Nuclear Magnetic Resonance Studies of the Apo Form of the c-MYC:MAX bHLHZip Complex Reveal a Helical Basic Region in the Absence of DNA. Biochemistry, 58, 2019
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6G6K
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![BU of 6g6k by Molmil](/molmil-images/mine/6g6k) | The crystal structures of Human MYC:MAX bHLHZip complex | 分子名称: | CHLORIDE ION, Myc proto-oncogene protein, Protein max | 著者 | Allen, M.D, Zinzalla, G. | 登録日 | 2018-04-01 | 公開日 | 2019-04-10 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Crystal Structures and Nuclear Magnetic Resonance Studies of the Apo Form of the c-MYC:MAX bHLHZip Complex Reveal a Helical Basic Region in the Absence of DNA. Biochemistry, 58, 2019
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6G6L
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![BU of 6g6l by Molmil](/molmil-images/mine/6g6l) | The crystal structures of Human MYC:MAX bHLHZip complex | 分子名称: | Myc proto-oncogene protein, Protein max, SULFATE ION | 著者 | Allen, M.D, Zinzalla, G. | 登録日 | 2018-04-01 | 公開日 | 2019-04-10 | 最終更新日 | 2023-04-05 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal Structures and Nuclear Magnetic Resonance Studies of the Apo Form of the c-MYC:MAX bHLHZip Complex Reveal a Helical Basic Region in the Absence of DNA. Biochemistry, 58, 2019
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6MGM
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![BU of 6mgm by Molmil](/molmil-images/mine/6mgm) | |
6MGN
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![BU of 6mgn by Molmil](/molmil-images/mine/6mgn) | mouse Id1 (51-104) - human hE47 (348-399) complex | 分子名称: | DNA-binding protein inhibitor ID-1, Transcription factor E2-alpha | 著者 | Benezra, R, Pavletich, N.P, Gall, A.-L, Goldgur, Y. | 登録日 | 2018-09-14 | 公開日 | 2019-09-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.901 Å) | 主引用文献 | A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization. Cell Rep, 29, 2019
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6OD3
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![BU of 6od3 by Molmil](/molmil-images/mine/6od3) | Human TCF4 C-terminal bHLH domain in Complex with 13-bp Oligonucleotide Containing E-box Sequence | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DNA (5'-D(*CP*AP*TP*AP*CP*AP*CP*GP*TP*GP*TP*AP*T)-3'), ... | 著者 | Horton, J.R, Cheng, X, Yang, J. | 登録日 | 2019-03-25 | 公開日 | 2019-05-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.494 Å) | 主引用文献 | Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine. Nucleic Acids Res., 47, 2019
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6OD4
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![BU of 6od4 by Molmil](/molmil-images/mine/6od4) | Human TCF4 C-terminal bHLH domain in Complex with 11-bp Oligonucleotide Containing E-box Sequence | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*TP*AP*CP*AP*CP*GP*TP*GP*TP*A)-3'), Transcription factor 4 | 著者 | Horton, J.R, Cheng, X, Yang, J. | 登録日 | 2019-03-25 | 公開日 | 2019-05-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.699 Å) | 主引用文献 | Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine. Nucleic Acids Res., 47, 2019
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6OD5
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![BU of 6od5 by Molmil](/molmil-images/mine/6od5) | Human TCF4 C-terminal bHLH domain in Complex with 12-bp Oligonucleotide Containing E-box Sequence with 5-carboxylcytosines | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DNA (5'-D(*AP*(1CC)P*GP*CP*AP*CP*GP*TP*GP*(1CC)P*G)-3'), ... | 著者 | Horton, J.R, Cheng, X, Yang, J. | 登録日 | 2019-03-25 | 公開日 | 2019-05-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine. Nucleic Acids Res., 47, 2019
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6U2U
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![BU of 6u2u by Molmil](/molmil-images/mine/6u2u) | |