6E3U

Crystal Structure of the Heterodimeric HIF-2 Complex with Agonist M1001

Summary for 6E3U

Related6E3S 6E3T
DescriptorAryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, 3-{[2-(pyrrolidin-1-yl)phenyl]amino}-1H-1lambda~6~,2-benzothiazole-1,1-dione (3 entities in total)
Functional Keywordscomplex, agonist, transcription factor, transcription, transcription-agonist complex, transcription/agonist
Biological sourceMus musculus (Mouse)
Total number of polymer chains2
Total molecular weight85921.75
Authors
Wu, D.,Su, X.,Lu, J.,Li, S.,Hood, B.,Vasile, S.,Potluri, N.,Diao, X.,Kim, Y.,Khorasanizadeh, S.,Rastinejad, F. (deposition date: 2018-07-15, release date: 2019-02-13, Last modification date: 2019-04-03)
Primary citation
Wu, D.,Su, X.,Lu, J.,Li, S.,Hood, B.L.,Vasile, S.,Potluri, N.,Diao, X.,Kim, Y.,Khorasanizadeh, S.,Rastinejad, F.
Bidirectional modulation of HIF-2 activity through chemical ligands.
Nat. Chem. Biol., 15:367-376, 2019
PubMed: 30804532 (PDB entries with the same primary citation)
DOI: 10.1038/s41589-019-0234-5
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.85 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.25920 0.2% 2.0% 2.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution