6E3U

Crystal Structure of the Heterodimeric HIF-2 Complex with Agonist M1001

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Aryl hydrocarbon receptor nuclear translocator	polymer	384	43437.4	1	UniProt (P53762) Pfam (PF00010) Pfam (PF00989) Pfam (PF14598) In PDB	Mus musculus (Mouse)	ARNT protein,Dioxin receptor,nuclear translocator,Hypoxia-inducible factor 1-beta,HIF1-beta
2	B	Endothelial PAS domain-containing protein 1	polymer	368	42157.0	1	UniProt (P97481) Pfam (PF00989) Pfam (PF14598) In PDB	Mus musculus (Mouse)	EPAS-1,HIF-1-alpha-like factor,mHLF,HIF-related factor,HRF,Hypoxia-inducible factor 2-alpha,HIF2-alpha
3	B	3-{[2-(pyrrolidin-1-yl)phenyl]amino}-1H-1lambda~6~,2-benzothiazole-1,1-dione	non-polymer		327.4	1	Chemie (HNJ)

Sequence modifications

A: 82 - 464 (UniProt: P53762)

PDB	External Database	Details
Met 81	-	initiating methionine

B: 3 - 362 (UniProt: P97481)

PDB	External Database	Details
Met 2	-	initiating methionine
Ala 318	Trp 318	engineered mutation
Glu 363	-	expression tag
His 364	-	expression tag
His 365	-	expression tag
His 366	-	expression tag
His 367	-	expression tag
His 368	-	expression tag
His 369	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	85594.4
Non-Polymers*	Number of molecules	1
	Total formula weight	327.4
All*	Total formula weight	85921.8

*Water molecules are not included.